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. 2020 Jan;287(1):73-93.
doi: 10.1111/febs.15070. Epub 2019 Oct 22.

P38α MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles

Maali Odeh  1 , Yael Tamir-Livne  1 , Tali Haas  2 , Eyal Bengal  1
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Free article

P38α MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles

Maali Odeh et al. FEBS J. 2020 Jan.
Free article

Abstract

Physiological or pathological muscle disuse/inactivity or loss of the neural-muscular junction cause muscle atrophy. Atrophy-inducing conditions cause metabolic oxidative stress in the muscle tissue, activation of the ubiquitin-proteasome and of the autophagosome-lysosome systems, enhanced removal of the damaged proteins and organelles, and loss of muscle mass and strength. The signaling pathways that control these catabolic processes are only partially known. In this study, we systematically analyzed the role of p38α mitogen-activated protein kinase (MAPK) in denervation-mediated atrophy. Mice with attenuated activity of p38α (p38AF ) are partially protected from muscle damage and atrophy. Denervated (Den) muscles of these mutant mice exhibit reduced signs of oxidative stress, decreased unfolded protein response and lower levels of ubiquitinated proteins relative to Den muscles of control mice. Further, whereas autopahagy flux is inhibited in Den muscles of control mice, Den muscles of p38AF mice maintain normal level of autophagy flux. Last, muscle denervation affects differently the energy metabolism of muscles in normal and mutant mice; whereas denervation appears to increase mitochondrial oxidative metabolism in control mice, it elevates anaerobic glycolytic metabolism in p38AF mice. Our results indicate, therefore, that attenuation of p38α activity in mice protects Den muscles by reducing oxidative stress, lowering protein damage and improving the clearance of damaged mitochondria by autophagy.

Keywords: denervation; energy metabolism; muscle atrophy; p38 MAPK; signal transduction.

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