Gut microbiota modulation with traditional Chinese medicine: A system biology-driven approach

doi:10.1016/j.phrs.2019.104453

Review

. 2019 Oct:148:104453.

doi: 10.1016/j.phrs.2019.104453. Epub 2019 Sep 18.

Gut microbiota modulation with traditional Chinese medicine: A system biology-driven approach

Shi-Jun Yue¹, Wen-Xiao Wang², Jin-Gao Yu², Yan-Yan Chen², Xu-Qin Shi³, Dan Yan⁴, Gui-Sheng Zhou³, Li Zhang³, Chang-Yun Wang⁵, Jin-Ao Duan³, Yu-Ping Tang⁶

Affiliations

¹ Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China; Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266000, China.
² Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China.
³ Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
⁴ Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Electronic address: yd277@126.com.
⁵ Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266000, China.
⁶ Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: yupingtang@sntcm.edu.cn.

PMID: 31541688
DOI: 10.1016/j.phrs.2019.104453

Review

Gut microbiota modulation with traditional Chinese medicine: A system biology-driven approach

Shi-Jun Yue et al. Pharmacol Res. 2019 Oct.

. 2019 Oct:148:104453.

doi: 10.1016/j.phrs.2019.104453. Epub 2019 Sep 18.

Authors

Shi-Jun Yue¹, Wen-Xiao Wang², Jin-Gao Yu², Yan-Yan Chen², Xu-Qin Shi³, Dan Yan⁴, Gui-Sheng Zhou³, Li Zhang³, Chang-Yun Wang⁵, Jin-Ao Duan³, Yu-Ping Tang⁶

Affiliations

¹ Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China; Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266000, China.
² Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China.
³ Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
⁴ Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Electronic address: yd277@126.com.
⁵ Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266000, China.
⁶ Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: yupingtang@sntcm.edu.cn.

PMID: 31541688
DOI: 10.1016/j.phrs.2019.104453

Abstract

With the development of system biology, traditional Chinese medicine (TCM) is drawing more and more attention nowadays. However, there are still many enigmas behind this ancient medical system because of the arcane theory and complex mechanism of actions. In recent decades, advancements in genome sequencing technologies, bioinformatics and culturomics have led to the groundbreaking characterization of the gut microbiota, a 'forgotten organ', and its role in host health and disease. Notably, gut microbiota has been emerging as a new avenue to understanding TCM. In this review, we will focus on the structure, composition, functionality and metabolites of gut microbiota affected by TCM so as to conversely understand its theory and mechanisms. We will also discuss the potential areas of gut microbiota for exploring Chinese material medica waste, Chinese marine material medica, add-on therapy and personalized precise medication of TCM. The review will conclude with future perspectives and challenges of gut microbiota in TCM intervention.

Keywords: Gut microbiota; Metabolic disorders; Personalized precise medication; Traditional Chinese medicine.

PubMed Disclaimer

Cited by

Huangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis.
Zhang Z, Ye J, Liu X, Zhao W, Zhao B, Gao X, Lan H, Wu Y, Yang Y, Cao P. Zhang Z, et al. Chin Med. 2023 Sep 7;18(1):114. doi: 10.1186/s13020-023-00826-5. Chin Med. 2023. PMID: 37679804 Free PMC article.
Impact of Phellinus gilvus mycelia on growth, immunity and fecal microbiota in weaned piglets.
Sun Y, Zhong S, Deng B, Jin Q, Wu J, Huo J, Zhu J, Zhang C, Li Y. Sun Y, et al. PeerJ. 2020 Apr 28;8:e9067. doi: 10.7717/peerj.9067. eCollection 2020. PeerJ. 2020. PMID: 32377455 Free PMC article.
Gut Microbiota Dysbiosis-Immune Hyperresponse-Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches.
Ferreira C, Viana SD, Reis F. Ferreira C, et al. Microorganisms. 2020 Oct 1;8(10):1514. doi: 10.3390/microorganisms8101514. Microorganisms. 2020. PMID: 33019592 Free PMC article. Review.
Esterases From Bifidobacteria Exhibit the Conversion of Albiflorin in Gut Microbiota.
Peng R, Han P, Fu J, Zhang ZW, Ma SR, Pan LB, Xia YY, Yu H, Xu H, Liu CX, Wang Y. Peng R, et al. Front Microbiol. 2022 Apr 6;13:880118. doi: 10.3389/fmicb.2022.880118. eCollection 2022. Front Microbiol. 2022. PMID: 35464989 Free PMC article.
Cross-Talk between Gut Microbiota and the Heart: A New Target for the Herbal Medicine Treatment of Heart Failure?
Li L, Zhong S, Cheng B, Qiu H, Hu Z. Li L, et al. Evid Based Complement Alternat Med. 2020 Apr 6;2020:9097821. doi: 10.1155/2020/9097821. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32328141 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
- Ovid Technologies, Inc.

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Gut microbiota modulation with traditional Chinese medicine: A system biology-driven approach

Affiliations

Gut microbiota modulation with traditional Chinese medicine: A system biology-driven approach

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources