Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

doi:10.1002/ptr.6508

Review

. 2019 Dec;33(12):3064-3089.

doi: 10.1002/ptr.6508. Epub 2019 Sep 12.

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Vipendra Kumar Singh^{1

2}, Deepika Arora^{1

3}, Mohammad Imran Ansari^{1

2}, Pradeep Kumar Sharma^{1

2}

Affiliations

¹ Environmental Carcinogenesis Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
² Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-, 201002, India.
³ Material and Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, 20899, Maryland, USA.

PMID: 31515899
DOI: 10.1002/ptr.6508

Review

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Vipendra Kumar Singh et al. Phytother Res. 2019 Dec.

. 2019 Dec;33(12):3064-3089.

doi: 10.1002/ptr.6508. Epub 2019 Sep 12.

Authors

Vipendra Kumar Singh^{1

2}, Deepika Arora^{1

3}, Mohammad Imran Ansari^{1

2}, Pradeep Kumar Sharma^{1

2}

Affiliations

¹ Environmental Carcinogenesis Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
² Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-, 201002, India.
³ Material and Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, 20899, Maryland, USA.

PMID: 31515899
DOI: 10.1002/ptr.6508

Abstract

Naturally occurring phytochemicals or plant derivatives are now being explored extensively for their health's benefits and medicinal uses. The therapeutic effect of phytochemicals has been reported in several pathophysiological settings such as inflammatory disorders, metabolic disorders, liver dysfunction, neurodegenerative disorders, and nephropathies. However, the most warranted therapeutic effects of phytochemicals were mapped to their anticancerous and chemopreventive action. Moreover, combining phytochemicals with standard chemotherapy has shown promising results in cancer therapy with minimal side effects and better efficacy. Many phytochemicals, like curcumin, resveratrol, and epigallocatechin-3-gallate, have been extensively investigated for their chemopreventive as well as chemotherapeutic effects. However, poor bioavailability, low solubility, hydrophobicity, and obscure target specificity restrict their therapeutic applications in the clinic. There has been a continually increasing interest to formulate nanoformulations of phytochemicals by using various nanocarriers, such as liposomes, micelles, nanoemulsions, and nanoparticles, to improve their bioavailability and target specificity, thereby maximizing the therapeutic potential. In the present review, we have summarized chemopreventive as well as chemotherapeutic action of some common phytochemicals and their major limitations in clinical application. Also, we have given an overview of strategies that can improve the efficacy of phytochemicals for their chemotherapeutic value in clinical settings.

Keywords: cancer; chemoprevention; curcumin; epigallocatechin-3-gallate; phytochemicals; resveratrol.

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References

REFERENCES

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1. Abusnina, A., Keravis, T., Yougbare, I., Bronner, C., & Lugnier, C. (2011). Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1. Molecular Nutrition & Food Research, 55(11), 1677-1689. https://doi.org/10.1002/mnfr.201100307
1. Afrin, S., Gasparrini, M., Tamara, Y., Forbes-Hernandez, P. R.-R., Mezzetti, B., … Battino, M. (2016). Promising health benefits of the strawberry: A focus on clinical studies. Journal of Agricultural and Food Chemistry, 64(22), 4435-4449. https://doi.org/10.1021/acs.jafc.6b00857
1. Aggarwal, B. B., & Shishodia, S. (2006). Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical Pharmacology, 71(10), 1397-1421. https://doi.org/10.1016/j.bcp.2006.02.009
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[1] Abbaoui, B., Lucas, C. R., Riedl, K. M., Clinton, S. K., & Mortazavi, A. (2018). Cruciferous vegetables, isothiocyanates, and bladder cancer prevention. Molecular Nutrition & Food Research, 62(18), e1800079. https://doi.org/10.1002/mnfr.201800079

[2] Abbaoui, B., Lucas, C. R., Riedl, K. M., Clinton, S. K., & Mortazavi, A. (2018). Cruciferous vegetables, isothiocyanates, and bladder cancer prevention. Molecular Nutrition & Food Research, 62(18), e1800079. https://doi.org/10.1002/mnfr.201800079

[3] Abusnina, A., Keravis, T., Yougbare, I., Bronner, C., & Lugnier, C. (2011). Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1. Molecular Nutrition & Food Research, 55(11), 1677-1689. https://doi.org/10.1002/mnfr.201100307

[4] Abusnina, A., Keravis, T., Yougbare, I., Bronner, C., & Lugnier, C. (2011). Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1. Molecular Nutrition & Food Research, 55(11), 1677-1689. https://doi.org/10.1002/mnfr.201100307

[5] Afrin, S., Gasparrini, M., Tamara, Y., Forbes-Hernandez, P. R.-R., Mezzetti, B., … Battino, M. (2016). Promising health benefits of the strawberry: A focus on clinical studies. Journal of Agricultural and Food Chemistry, 64(22), 4435-4449. https://doi.org/10.1021/acs.jafc.6b00857

[6] Afrin, S., Gasparrini, M., Tamara, Y., Forbes-Hernandez, P. R.-R., Mezzetti, B., … Battino, M. (2016). Promising health benefits of the strawberry: A focus on clinical studies. Journal of Agricultural and Food Chemistry, 64(22), 4435-4449. https://doi.org/10.1021/acs.jafc.6b00857

[7] Aggarwal, B. B., & Shishodia, S. (2006). Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical Pharmacology, 71(10), 1397-1421. https://doi.org/10.1016/j.bcp.2006.02.009

[8] Aggarwal, B. B., & Shishodia, S. (2006). Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical Pharmacology, 71(10), 1397-1421. https://doi.org/10.1016/j.bcp.2006.02.009

[9] Ali, K., Maltese, F., Choi, Y. H., & Verpoorte, R. (2010). Metabolic constituents of grapevine and grape-derived products. Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe, 9(3), 357-378. https://doi.org/10.1007/s11101-009-9158-0

[10] Ali, K., Maltese, F., Choi, Y. H., & Verpoorte, R. (2010). Metabolic constituents of grapevine and grape-derived products. Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe, 9(3), 357-378. https://doi.org/10.1007/s11101-009-9158-0

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Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Affiliations

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

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Abstract

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