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. 2019 Sep 4;14(1):296.
doi: 10.1186/s13018-019-1301-z.

Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma

Hongzeng Wu  1 , Jinming Zhang  1 , Ruoheng Dai  2 , Jianfa Xu  1 , Helin Feng  3
Affiliations

Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma

Hongzeng Wu et al. J Orthop Surg Res. .

Abstract

Background: Osteosarcoma is aggressive and prognostic biomarkers are important to predict the outcomes of surgery and chemotherapy. Here, we investigated the potential of transferrin receptor-1 (TfR1) and vascular endothelial growth factor (VEGF) as prognostic markers of osteosarcoma.

Methods: TfR1 and VEGF in osteosarcoma samples from a cohort of 53 osteosarcoma patients were detected by immunohistochemistry analysis. The correlation of TfR1 and VEGF levels with clinicopathological parameters was analyzed by Pearson chi-square and Spearman-rho tests. Overall patient survival was analyzed by the Kaplan-Meier method.

Results: We found that TfR1 and VEGF expression levels were low in 20.8% and 18.9%; modest in 35.8% and 35.8%; and high in 43.4% and 45.3% of osteosarcoma patients, respectively. TfR1 and VEGF expression was significantly correlated to histologic grade, Enneking stage, and distant metastasis. TfR1 expression was significantly correlated to VEGF expression and both TfR1 expression and VEGF expression were correlated to shorter overall survival.

Conclusions: TfR1 and VEGF are potential prognostic factors for osteosarcoma.

Keywords: Osteosarcoma; Prognosis; Transferrin receptor-1; VEGF.

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Conflict of interest statement

All authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Representative immunohistochemical staining of TfR1 and VEGF. a High expression of TfR1 in OS. c Moderate expression of TfR1 in OS. e Low expression of TfR1 in OS. b High expression of VEGF in OS. d Moderate expression of VEGF in OS. f Low expression of VEGF in OS. The cells with positive expression were stained brown
Fig. 2
Fig. 2
Overall survival curves of patients with OS. a Association of overall survival with distant metastasis. b Association of overall survival with TfR1 expression. c Association of overall survival with VEGF expression. d Association of overall survival with clinical stage
See this image and copyright information in PMC

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