Surgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association

doi:10.1007/s10120-019-01000-3

. 2020 Mar;23(2):328-338.

doi: 10.1007/s10120-019-01000-3. Epub 2019 Aug 26.

Surgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association

Affiliations

¹ Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. souya.nunobe@jfcr.or.jp.
² Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
³ Department of Medical Informatics, Niigata University Medical and Dental Hospital, Niigata, Japan.
⁴ Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan.
⁵ Department of Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
⁶ Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
⁷ Department of Gastroenterological Surgery, Tottori University, Tottori, Japan.
⁸ Endoscopy Division, Shizuoka Cancer Center, Shizuoka, Japan.
⁹ Department of Advanced Medicine, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.
¹⁰ Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
¹¹ Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

PMID: 31451990
DOI: 10.1007/s10120-019-01000-3

Surgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association

Souya Nunobe et al. Gastric Cancer. 2020 Mar.

. 2020 Mar;23(2):328-338.

doi: 10.1007/s10120-019-01000-3. Epub 2019 Aug 26.

Affiliations

¹ Department of Gastroenterological Surgery, Cancer Institute Ariake Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. souya.nunobe@jfcr.or.jp.
² Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
³ Department of Medical Informatics, Niigata University Medical and Dental Hospital, Niigata, Japan.
⁴ Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan.
⁵ Department of Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
⁶ Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
⁷ Department of Gastroenterological Surgery, Tottori University, Tottori, Japan.
⁸ Endoscopy Division, Shizuoka Cancer Center, Shizuoka, Japan.
⁹ Department of Advanced Medicine, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.
¹⁰ Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
¹¹ Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

PMID: 31451990
DOI: 10.1007/s10120-019-01000-3

Abstract

Background: The proportion of elderly patients undergoing surgery for gastric cancer is increasing. However, limited number of therapeutic outcomes in the elderly has been reported. Here we examined the surgical results based on a nationwide survey of elderly patients who underwent surgery for Stage I gastric cancer.

Methods: Data from 68,353 Stage I patients who underwent gastrectomy between 2001 and 2007 were retrospectively collected. The accumulated data were reviewed and analyzed by the Japanese Gastric Cancer Association registration committee. We first classified the patients as those aged ≤ 74 years and ≥ 75 years. We further classified those patients aged ≥ 75 years into groups by 5-year increments to examine their short- and long-term postoperative outcomes.

Results: Patients aged ≥ 75 years accounted for 46.5%. The 30-day mortality rate was < 0.7% for any age group, but for those aged ≥ 75 years, the 60-day and 90-day mortality rates were 0.9-2.3% and 1.2-5.1%, respectively. An examination of long-term survival indicated that, as the class of age increased, the 5-year overall survival (OS) was 47.0-93.1% and disease-specific survival (DSS) was 91.4-98.2%, respectively. Although high DSS rates of ≥ 90% were found for all age groups, OS only accounted for ≤ 82% of patients aged ≥ 75 years.

Conclusion: Among elderly patients with Stage I gastric cancer, deaths due to other diseases were frequently observed in the long term. Thus, for elderly patients, it may be appropriate to reconsider the treatment strategy with respect to the balance between the invasiveness of the treatment and the prognosis.

Keywords: Elderly patients; Nationwide survey; Stage I gastric cancer.

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References

1. https://www.mhlw.go.jp/toukei/saikin/hw/life/life17/index.html , Ministry of Health, Labour and Welfare. Accessed 11 May 2018
1. Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter. 2001;6:294–9. - DOI
1. Katai H, Ishikawa T, Akazawa K, Isobe Y, Miyashiro I, Oda I, et al. Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001–2007). Gastric Cancer. 2018;21:144–54. - DOI
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1. Kunisaki C, Miyata H, Konno H, Saze Z, Hirahara N, Kikuchi H, et al. Modeling preoperative risk factors for potentially lethal morbidities using a nationwide Japanese web-based database of patients undergoing distal gastrectomy for gastric cancer. Gastric Cancer. 2017;20:496–507. - DOI

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[1] https://www.mhlw.go.jp/toukei/saikin/hw/life/life17/index.html , Ministry of Health, Labour and Welfare. Accessed 11 May 2018

[2] https://www.mhlw.go.jp/toukei/saikin/hw/life/life17/index.html , Ministry of Health, Labour and Welfare. Accessed 11 May 2018

[3] Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter. 2001;6:294–9. - DOI

[4] Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter. 2001;6:294–9. - DOI

[5] Katai H, Ishikawa T, Akazawa K, Isobe Y, Miyashiro I, Oda I, et al. Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001–2007). Gastric Cancer. 2018;21:144–54. - DOI

[6] Katai H, Ishikawa T, Akazawa K, Isobe Y, Miyashiro I, Oda I, et al. Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001–2007). Gastric Cancer. 2018;21:144–54. - DOI

[7] Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma. 14th ed. Tokyo: Kanehara; 2018.

[8] Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma. 14th ed. Tokyo: Kanehara; 2018.

[9] Kunisaki C, Miyata H, Konno H, Saze Z, Hirahara N, Kikuchi H, et al. Modeling preoperative risk factors for potentially lethal morbidities using a nationwide Japanese web-based database of patients undergoing distal gastrectomy for gastric cancer. Gastric Cancer. 2017;20:496–507. - DOI

[10] Kunisaki C, Miyata H, Konno H, Saze Z, Hirahara N, Kikuchi H, et al. Modeling preoperative risk factors for potentially lethal morbidities using a nationwide Japanese web-based database of patients undergoing distal gastrectomy for gastric cancer. Gastric Cancer. 2017;20:496–507. - DOI

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Surgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association

Affiliations

Surgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association

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