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. 2020 Feb;13(1):64-68.
doi: 10.21053/ceo.2019.00395. Epub 2019 Aug 27.

Expression of Serum PTTG1 in Laryngeal Carcinoma and Its Correlation to Prognosis

Kunpeng Ma  1 , Xiuxia Sun  1 , Limin Ma  2 , Shenglin Zhang  3
Affiliations

Expression of Serum PTTG1 in Laryngeal Carcinoma and Its Correlation to Prognosis

Kunpeng Ma et al. Clin Exp Otorhinolaryngol. 2020 Feb.

Abstract

Objectives: The purpose of this study was to investigate serum pituitary tumor transforming gene (PTTG1) expression in laryngeal carcinoma and its relationship with the clinical pathological characteristics and prognosis.

Methods: Expression of serum PTTG1 was measured by enzyme-linked immunosorbent assay in 110 patients with laryngeal carcinoma and 60 patients with vocal cord polyps. Expression of the serum PTTG1 levels relationship with the clinicopathological characteristics and prognosis were analyzed.

Results: In laryngeal carcinoma patients' serum, the PTTG1 median concentration was 141.43 pg/mL (interquartile range [IQR], 111.387 to 160.837 pg/mL), significantly higher than that of the vocal cord polyp group of 94.01 pg/mL (IQR, 81.26 to 108.59 pg/mL), and the difference was statistically significant (z=-6.715, P<0.001). PTTG1 expression with lymph node metastasis, clinical stage, and patients with laryngeal carcinoma was significantly correlated with the tumor differentiation degree (P<0.05). The total survival rate of the PTTG1 high expression group was significantly lower than the low expression group, and the difference of total survival time of the two groups was statistically significant (P<0.001).

Conclusion: The PTTG1 expression level can be used as an index for evaluating prognosis of laryngeal cancer. High PTTG1 expression is one of the factors of poor prognosis of laryngeal carcinoma patients.

Keywords: Laryngeal Cancer; Prognosis; Serum; Transforming Genes.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
The serum level of PTTG1 in the laryngeal cancer group and the control group. The median concentration of serum PTTG1 in laryngeal cancer patients was significantly higher than that in the vocal cord polyp group. There was a significant difference (P<0.001).
Fig. 2.
Fig. 2.
The receiver operating characteristic curve of PTTG1 expression in the serum of laryngeal cancer patients. PTTG1 has high sensitivity and specificity in the serum of laryngeal cancer patients. The sensitivity was 88.5%, the specificity was 85.7%, and the area under the curve was 0.933.
Fig. 3.
Fig. 3.
The survival curve of PTTG1 patients with high and low expression. Kaplan-Meier analysis of the total survival time of the PTTG1 high-expression group and the low-expression group showed that the total survival time of the PTTG1 high-expression group was significantly lower than that of the low-expression group, and the difference in total survival time between the two groups was significant (P<0.001).
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