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. 1988 Dec 23;55(6):1025-35.
doi: 10.1016/0092-8674(88)90247-4.

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

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The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

H Amrein et al. Cell. .

Erratum in

  • Cell 1989 Jul 28;58(2):following 419

Abstract

The gene transformer-2 (tra-2) of Drosophila is necessary not only for female sexual differentiation but also for normal spermatogenesis in males. We have cloned and characterized the tra-2 gene. Its putative protein has a domain that is homologous to RNA binding proteins. This suggests that the tra-2 protein might achieve the female-specific splicing of the transcript of dsx, a sex-determining gene whose mode of expression depends on tra-2. The protein coding region of the tra-2 transcript is identical in males and females. In both sexes, a low level of transcript is present in the soma and a high level in the germ line. This indicates that tra-2 is regulated in a way different from other sex-determining genes.

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