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Review
. 2019 Aug 8;26(1):57.
doi: 10.1186/s12929-019-0552-7.

Enterovirus A71 neurologic complications and long-term sequelae

Luan-Yin Chang  1 , Hsiang-Yuan Lin  2 , Susan Shur-Fen Gau  2 , Chin-Yu Lu  3 , Shao-Hsuan Hsia  4 , Yhu-Chering Huang  4 , Li-Min Huang  3 , Tzou-Yien Lin  4
Affiliations
Review

Enterovirus A71 neurologic complications and long-term sequelae

Luan-Yin Chang et al. J Biomed Sci. .

Abstract

During recent 20 years, enterovirus A71 (EV-A71) has emerged as a major concern among pediatric infectious diseases, particularly in the Asia-Pacific region. The clinical manifestations of EV-A71 include uncomplicated hand, foot, and mouth disease, herpanina or febrile illness and central nervous system (CNS) involvement such as aseptic meningitis, myoclonic jerk, polio-like syndrome, encephalitis, encephalomyelitis and cardiopulmonary failure due to severe rhombencephalitis. In follow-up studies of patients with EV-A 71 CNS infection, some still have hypoventilation and need tracheostomy with ventilator support, some have dysphagia and need nasogastric tube or gastrostomy feeding, some have limb weakness/astrophy, cerebellar dysfunction, neurodevelopmental delay, lower cognition, or attention deficiency hyperactivity disorder. Long term sequelae may be related to greater severity of CNS involvement or neuron damage, hypoxia and younger age of onset.

Keywords: Age of onset; Attention deficiency hyperactivity disorder; Cognition; Encephalitis; Enterovirus A71; Polio-like syndrome; Rhombencephalitis; Sequelae; Tracheostomy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
A child who had tracheostomy with ventilator support because he had central hypoventilation
Fig. 2
Fig. 2
High-intensity lesions in the tegmentum of the brain stem (black arrow) and high-intensity lesions in the cervical spinal cord (gray arrow) on the T2-weighted image of MRI in a case with the sequelae of central hypoventilation and right upper limb weakness and atrophy
Fig. 3
Fig. 3
A boy who had left shoulder subluxation and left arm atrophy (arrow) due to polio-like syndrome
See this image and copyright information in PMC

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References

    1. Schmidt NJ, Lennette EH, Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis. 1974;129:304–309. doi: 10.1093/infdis/129.3.304. - DOI - PubMed
    1. Shindarov LM, Chumakov MP, Voroshilova MK, et al. Epidemiological, clinical and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by enterovirus 71. J Hyg Epidemiol Microbiol Immunol. 1979;23:284–295. - PubMed
    1. Nagy G, Takatsy S, Kukan E, Mihaly I, Domok I. Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978. Arch Virol. 1982;71:217–227. doi: 10.1007/BF01314873. - DOI - PubMed
    1. Chan LG, Parashar UD, Lye MS, et al. Deaths of children during an outbreak of hand, foot, and mouth disease in Sarawak, Malaysia: clinical and pathological characteristics of the disease. Clin Infect Dis. 2000;31:678–683. doi: 10.1086/314032. - DOI - PubMed
    1. Centers for Diseases Control and Prevention Deaths among children during an outbreak of hand, foot, and mouth disease -- Taiwan, Republic of China, April–July 1998. MMWR Morb Mortal Wkly Rep. 1998;47:629–632. - PubMed

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