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Review
. 2019 Jun 28:11:143-156.
doi: 10.2147/OARRR.S206931. eCollection 2019.

Biomarkers of subclinical atherosclerosis in patients with psoriatic arthritis

Rosario Peluso  1 , Francesco Caso  1 , Marco Tasso  1 , Vincenzo Sabbatino  1 , Roberta Lupoli  2 , Matteo Nicola Dario Di Minno  3 , Francesco Ursini  4 , Luisa Costa  1 , Raffaele Scarpa  1
Affiliations
Review

Biomarkers of subclinical atherosclerosis in patients with psoriatic arthritis

Rosario Peluso et al. Open Access Rheumatol. .

Abstract

Background: Psoriatic arthritis (PsA) is a chronic immune-mediated disease. It is associated with an increase in cardiovascular risk factors (obesity, hypertension, diabetes, and dyslipidemia), giving a higher risk of major adverse cardiovascular events. Patients with PsA have an increased incidence of subclinical atherosclerosis and endothelial dysfunction. The aim of this study is to perform a review of the biomarkers of subclinical atherosclerosis in patients with PsA. Methods: A search was performed in the electronic databases (PubMed, Web of Science, Scopus, and Embase) up until July 2017. Studies were considered if they included data on biomarkers of subclinical atherosclerosis in PsA, and each article was then reviewed for quality and clinical relevance. After completing the literature search, all screened literature was summarized and discussed in our study group (CaRRDs study group). Results: The initial search produced 532 abstracts, which were limited to 258 potentially relevant articles by preliminary review of the titles and by excluding review articles and case reports (n=274). A further 102 articles were deemed ineligible after examining the abstracts. Full texts of the remaining 156 articles were retrieved. Most articles were excluded because they were not relevant to the biomarkers of subclinical atherosclerosis in psoriasis and/or PsA. In the end, 54 articles were deemed eligible for this review. Conclusion: Patients with PsA showed more severe atherosclerotic disease compared with patients with only psoriasis. This may have been due to the higher systemic inflammatory burden from the combination of both diseases. In patients with PsA some molecules may be considered as markers of atherosclerotic disease, and their detection may be a prognostic marker, in addition to imaging procedures, for the development of atherosclerotic disease, and could be suitable for the management of patients with PsA.

Keywords: complement C3; insulin resistance; lipid profile; primary and secondary hemostasis; psoriatic disease; serum uric acid.

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Conflict of interest statement

RS, RP, LC, FC, and MNDDM have acted as paid lecturers or board members and received grants and honoraria in the past 36 months for research unrelated to the present study. RP is a member of the Editorial Board for BMC Muscoskeletal Disorders. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of the literature review process (adapted from the PRISMA flow diagram).
See this image and copyright information in PMC

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