The intestinal microbiota fuelling metabolic inflammation

doi:10.1038/s41577-019-0198-4

Review

. 2020 Jan;20(1):40-54.

doi: 10.1038/s41577-019-0198-4. Epub 2019 Aug 6.

The intestinal microbiota fuelling metabolic inflammation

Herbert Tilg¹, Niv Zmora^{2

3

4}, Timon E Adolph⁵, Eran Elinav^{6

7}

Affiliations

¹ Department of Internal Medicine, Gastroenterology, Hepatology, Metabolism & Endocrinology, Medical University Innsbruck, Innsbruck, Austria. herbert.tilg@i-med.ac.at.
² Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
³ Digestive Centre, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel.
⁴ Department of Internal Medicine, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel.
⁵ Department of Internal Medicine, Gastroenterology, Hepatology, Metabolism & Endocrinology, Medical University Innsbruck, Innsbruck, Austria.
⁶ Immunology Department, Weizmann Institute of Science, Rehovot, Israel. eran.elinav@weizmann.ac.il.
⁷ Cancer-Microbiome Division, Deutsches Krebsforschungszentrum (DKFZ), Neuenheimer Feld 280, Heidelberg, Germany. eran.elinav@weizmann.ac.il.

PMID: 31388093
DOI: 10.1038/s41577-019-0198-4

Review

The intestinal microbiota fuelling metabolic inflammation

Herbert Tilg et al. Nat Rev Immunol. 2020 Jan.

. 2020 Jan;20(1):40-54.

doi: 10.1038/s41577-019-0198-4. Epub 2019 Aug 6.

Authors

Herbert Tilg¹, Niv Zmora^{2

3

4}, Timon E Adolph⁵, Eran Elinav^{6

7}

Affiliations

¹ Department of Internal Medicine, Gastroenterology, Hepatology, Metabolism & Endocrinology, Medical University Innsbruck, Innsbruck, Austria. herbert.tilg@i-med.ac.at.
² Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
³ Digestive Centre, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel.
⁴ Department of Internal Medicine, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel.
⁵ Department of Internal Medicine, Gastroenterology, Hepatology, Metabolism & Endocrinology, Medical University Innsbruck, Innsbruck, Austria.
⁶ Immunology Department, Weizmann Institute of Science, Rehovot, Israel. eran.elinav@weizmann.ac.il.
⁷ Cancer-Microbiome Division, Deutsches Krebsforschungszentrum (DKFZ), Neuenheimer Feld 280, Heidelberg, Germany. eran.elinav@weizmann.ac.il.

PMID: 31388093
DOI: 10.1038/s41577-019-0198-4

Abstract

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2 diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites, which translocate from the gut across a disrupted intestinal barrier to affect various metabolic organs, such as the liver and adipose tissue, thereby contributing to metabolic inflammation. Here, we discuss some of the recently identified mechanisms that showcase the role of the intestinal microbiota and barrier dysfunction in metabolic inflammation. We propose a concept by which the gut microbiota fuels metabolic inflammation and dysregulation.

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The intestinal microbiota fuelling metabolic inflammation

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The intestinal microbiota fuelling metabolic inflammation

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