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Review
. 2019 Aug 2;8(8):815.
doi: 10.3390/cells8080815.

Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

Anne-Sophie Lamort  1 , Ioanna Giopanou  2 , Ioannis Psallidas  3 , Georgios T Stathopoulos  4   5
Affiliations
Review

Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

Anne-Sophie Lamort et al. Cells. .

Abstract

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.

Keywords: OPN; SPP1; inflammation; lung cancer; secreted phosphoprotein 1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of the human osteopontin (OPN) gene and protein variants. (A) Part of chromosome 4 with the SPP1 locus (red rectangle). (B) Structure of the SPP1 gene. White boxes, untranslated exons; black boxes, translated exons; black line, introns. (C) Exon composition of the protein variants resulting from alternative splicing.
Figure 2
Figure 2
SPP1 expression in physiologic conditions and cancer. SPP1 mRNA expression was ranked as low, medium, and high. Low, <500 transcripts per million; medium, 500–1000 transcripts per million; high, >1000 transcripts per million. SPP1 protein expression was ranked as low, medium, and high. Low, expression by <25% of individuals tested; medium, expression by 25–50% of individuals tested; high, expression by >50% of individuals tested. RNA-seq and immunohistochemistry data were from The Human Protein Atlas (https://www.proteinatlas.org/).
Figure 3
Figure 3
Overall survival in lung cancers according to SPP1 expression. Data and plot from http://kmplot.com/.
See this image and copyright information in PMC

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