The prognostic role of tumour-infiltrating lymphocytes in oral squamous cell carcinoma: A meta-analysis
- PMID: 31323145
- DOI: 10.1111/jop.12927
The prognostic role of tumour-infiltrating lymphocytes in oral squamous cell carcinoma: A meta-analysis
Abstract
It has been suggested that tumour-infiltrating lymphocytes (TILs) are associated with the progression of oral squamous cell carcinoma (OSCC). However, the prognostic value of TILs is inconclusive due to the heterogeneity of immune cells within the tumour microenvironment. In this meta-analysis, we aimed to assess the prognostic value of TILs in OSCC. The PubMed, Cochrane, Embase, Scopus and Web of Science databases were searched up to April 20, 2019, and 33 studies were ultimately included in this meta-analysis. Our pooled meta-analysis showed that high infiltration of CD8+ TILs, CD45RO+ TILs and CD57+ TILs favoured better overall survival (OS). However, high infiltration of CD68+ macrophages and CD163+ macrophages was associated with poor prognosis in OSCC. These findings suggest that CD8+ TILs, CD45RO+ TILs, CD57+ TILs, CD68+ macrophages and CD163+ macrophages might serve as novel prognostic factors and therapeutic targets in OSCC.
Keywords: lymph node metastasis; oral squamous cell carcinoma; prognostic factor; survival; tumour-infiltrating lymphocytes.
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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References
REFERENCES
-
- Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
-
- LeHew CW, Weatherspoon DJ, Peterson CE, et al. The health system and policy implications of changing epidemiology for oral cavity and oropharyngeal cancers in the United States from 1995 to 2016. Epidemiol Rev. 2017;39(1):132-147.
-
- Lydiatt WM, Patel SG, O'Sullivan B, et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):122-137.
-
- Zhu Y, Liu H, Xie N, et al. Impact of tumor budding in head and neck squamous cell carcinoma: a meta-analysis. Head Neck. 2019;41(2):542-550.
-
- Binnewies M, Roberts EW, Kersten K, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018;24(5):541-550.
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