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. 2019 Jul 17;16(14):2555.
doi: 10.3390/ijerph16142555.

Secular Trends in Lipid Profiles in Korean Adults Based on the 2005-2015 KNHANES

Yu-Jin Kwon  1   2   3 , Jae-Woo Lee  4   5 , Hee-Taik Kang  6   7
Affiliations

Secular Trends in Lipid Profiles in Korean Adults Based on the 2005-2015 KNHANES

Yu-Jin Kwon et al. Int J Environ Res Public Health. .

Abstract

Dyslipidemia is a primary, critical risk factor for cardiovascular disease. Therefore, evaluating the trends in lipid profiles is crucial for the development of health policies and programs. We studied trends in lipid profiles in Korean adults over an 11-year period according to the use of lipid-lowering medications through age-specific analysis. A total of 73,890 participants were included in the Korean National Health and Nutrition Examination Survey III (2005)-VI (2013-2015). The proportion of participants on lipid-lowering medications has increased. This trend was apparent in age groups of over 40 years in both men and women. Lipid-lowering medications successfully reduced mean total cholesterol (TC), but there was no favorable trend in TC in participants not taking lipid-lowering medication in both men and women. Unlike men, triglyceride and non-high-density lipoprotein cholesterol (HDL) decreased in women without lipid-lowering medications. In age-specific hypercholesterolemia, the prevalence of hypercholesterolemia significantly increased in the age groups of 30-59 and 30-49 years in men and women without lipid-lowering medications, respectively. Meanwhile, mean HDL-C levels increased over the 11-year period regardless of lipid-lowering drug use in both men and women. These analyses identified an upward trend in TC and HDL-C over the 11-year period.

Keywords: dyslipidemia; high-density lipoprotein cholesterol; prevalence; total cholesterol; triglyceride.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Age-adjusted and age-specific prevalence of use of lipid-lowering medication. (A) Men; (B) women. p-values for trends were determined by logistic regression analyses after setting the KNHANES phase as the continuous variable. KNHANES: Korean National Health and Nutrition Examination Survey.
Figure 2
Figure 2
Trends in age-adjusted prevalence of hypercholesterolemia, hypertriglyceridemia, and hypo-HDL-cholesterolemia in subjects with no use of lipid-lowering medication. (A) Hypercholesterolemia. (B) Hypertriglyceridemia. (C) Hypo-HDL-cholesterolemia. P-values for trends were determined by logistic regression analyses after setting the KNHANES phase as the continuous variable. KNHANES: Korean National Health and Nutrition Examination Survey.
Figure 3
Figure 3
Trends in age-specific prevalence of hypercholesterolemia, hypertriglyceridemia, and hypo-HDL-cholesterolemia in subjects with no use of lipid-lowering medication. (a) Hypercholesterolemia; (b) hypertriglyceridemia; (c) hypo-HDL-cholesterolemia.
Figure 3
Figure 3
Trends in age-specific prevalence of hypercholesterolemia, hypertriglyceridemia, and hypo-HDL-cholesterolemia in subjects with no use of lipid-lowering medication. (a) Hypercholesterolemia; (b) hypertriglyceridemia; (c) hypo-HDL-cholesterolemia.
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