Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application
- PMID: 31300111
- DOI: 10.1016/j.cimid.2019.05.013
Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application
Abstract
Goatpox (GTP), sheeppox (SPP) and lumpy skin disease (LSD) are three severe diseases of goat, sheep and cattle. Their typical clinical symptoms are characterized by vesicles, papules, nodules, pustules and scabs on animal skins. The GTP, SPP and LSD are caused by goatpox virus (GTPV), sheeppox virus (SPPV) and lumpy skin disease virus (LSDV), respectively, all of which belong to the genus Capripoxvirus in the family Poxviridae. Several capripoxvirus (CaPV) isolates have been virulently attenuated through serial passaging in vitro for production of live vaccines. CaPV-based vector systems have been broadly used to construct recombinant vaccines for delivering foreign antigens, many of which have been demonstrated to induce effective immune protections. Homologous recombination is the most commonly used method for constructing recombinant CaPVs. Here, we described a methodology for generation of recombinant CaPVs by the homologous recombination, and further reviewed CaPV-vectored vaccines for delivering foreign antigens.
Keywords: CaPV-vectored vaccine; Capripoxviruses; Homologous recombination; Immune response; Methodology; Recombinant CaPV.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Similar articles
-
A gel-based PCR method to differentiate sheeppox virus field isolates from vaccine strains.Virol J. 2018 Apr 2;15(1):59. doi: 10.1186/s12985-018-0969-8. Virol J. 2018. PMID: 29609650 Free PMC article.
-
Capripox disease in Ethiopia: Genetic differences between field isolates and vaccine strain, and implications for vaccination failure.Antiviral Res. 2015 Jul;119:28-35. doi: 10.1016/j.antiviral.2015.04.008. Epub 2015 Apr 20. Antiviral Res. 2015. PMID: 25907637
-
Comparative sequence and structural analysis of the ORF095 gene, a vaccinia virus A4L homolog of capripoxvirus in sheep and goats.Arch Virol. 2020 Jun;165(6):1419-1431. doi: 10.1007/s00705-020-04623-5. Epub 2020 Apr 19. Arch Virol. 2020. PMID: 32307603
-
Vaccines for lumpy skin disease, sheep pox and goat pox.Dev Biol (Basel). 2003;114:161-7. Dev Biol (Basel). 2003. PMID: 14677686 Review.
-
Control of capripoxvirus infections.Vaccine. 1993 Oct;11(13):1275-9. doi: 10.1016/0264-410x(93)90094-e. Vaccine. 1993. PMID: 8296478 Review.
Cited by
-
Construction and purification of ANK gene deleted recombinant goatpox virus.Virusdisease. 2020 Dec;31(4):526-533. doi: 10.1007/s13337-020-00620-z. Epub 2020 Aug 10. Virusdisease. 2020. PMID: 33381625 Free PMC article.
-
NF-κB as an Important Factor in Optimizing Poxvirus-Based Vaccines against Viral Infections.Pathogens. 2020 Nov 29;9(12):1001. doi: 10.3390/pathogens9121001. Pathogens. 2020. PMID: 33260450 Free PMC article. Review.
-
Review of sheep and goat pox disease: current updates on epidemiology, diagnosis, prevention and control measures in Ethiopia.Anim Dis. 2021;1(1):28. doi: 10.1186/s44149-021-00028-2. Epub 2021 Nov 15. Anim Dis. 2021. PMID: 34806086 Free PMC article. Review.
-
Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV.Vaccines (Basel). 2021 Nov 5;9(11):1281. doi: 10.3390/vaccines9111281. Vaccines (Basel). 2021. PMID: 34835214 Free PMC article.
-
Advancements in the Growth and Construction of Recombinant Lumpy Skin Disease Virus (LSDV) for Use as a Vaccine Vector.Vaccines (Basel). 2021 Oct 4;9(10):1131. doi: 10.3390/vaccines9101131. Vaccines (Basel). 2021. PMID: 34696239 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
