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. 2019 Jul 11;19(1):72.
doi: 10.1186/s12902-019-0403-2.

The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy

Song Guo  1 , Jun Zhang  1 , Yanhong Li  1 , Huamei Ma  1 , Qiuli Chen  1 , Hongshan Chen  1 , Minlian Du  2
Affiliations

The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy

Song Guo et al. BMC Endocr Disord. .

Abstract

Background: Further knowledge about the pubertal development mode of girls with Turner syndrome (TS) who have undergone hormone replacement therapy (HRT) is beneficial to the proposal of an optimal HRT regimen. This study examined the pubertal development mode of girls with TS who underwent HRT and evaluated the characteristics of optimal sex induction therapy in girls with TS.

Method: We conducted a retrospective, longitudinal study over the past two decades at The First Affiliated Hospital, Sun Yat-sen University.

Patients: Seventy-one patients with TS and two groups of normal Chinese girls.

Results: The total investigation time was 3.00 (2.00, 4.66) years. The interval of each stage was significantly longer (P < 0.001) in the girls with TS than that in the normal Chinese girls, except for B2-3 (P = 0.011). The uterine volumes of the girls with TS in stages B2 and 3 were greater than those of the control group (P = 0.046), whereas the uterine volume of the control group was inversely greater than that of the TS group among those who reached stages B4 and 5 (P = 0.034). During HRT, the uterine volume grew significantly from all previous stages except for breast stage 5 (B3 vs.2: Z = - 2.031; P = 0.042; B4 vs. 3: Z = - 2.273; P = 0.023; B5 vs. 4: Z = - 1.368; P = 0.171). The paired data of 27 girls with TS showed that the uterine volume (17.93 ± 9.31 ml vs. 13.75 ± 6.67 ml) and width (2.54 ± 0.66 cm vs. 2.22 ± 0.36 cm) increased significantly during artificial cycles compared with before artificial cycles (t = - 2.79 and - 2.51, P = 0.01 and 0.018).

Conclusion: HRT led to normal breast development in girls with TS; half of the girls with TS in our study reached Tanner stage B5, although the uterus ultimately developed suboptimally. The girls' breasts and uteruses grew quickly at the beginning of HRT (stages B2-4). An optimal HRT regimen for girls with TS may specifically focus on Tanner stages B2-4 and artificial cycles.

Keywords: Breast; Hormone replacement therapy (HRT); Tanner stage; Turner syndrome; Uterus.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
a and b Breast curves of 39 girls with TS who reached final breast stage and 139 normally developing girls. We computed the percentage of girls in each breast stage every 0.5 years starting at age 12 years and graphed them as the curves of age composition in breast stages B3 to B5 for girls with TS (the curve for girls with B2 was excluded because of the small sample size) (a) and normally developing Chinese girls (b)
See this image and copyright information in PMC

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References

    1. Calcaterra V, Lanzarini L, Guerci B, Mancini L, Giovenale D, Scaglia F, Albanesi M, Larizza D. Pregnancy in a woman with turner syndrome and celiac disease. J Endocrinol Investig. 2007;30:598–600. doi: 10.1007/BF03346354. - DOI - PubMed
    1. de Ziegler D, Pirtea P, Galliano D, Cicinelli E, Meldrum D. Optimal uterine anatomy and physiology necessary for normal implantation and placentation. Fertil Steril. 2016;105:844–854. doi: 10.1016/j.fertnstert.2016.02.023. - DOI - PubMed
    1. Abir R, Fisch B, Nahum R, Orvieto R, Nitke S, Ben RZ. Turner's syndrome and fertility: current status and possible putative prospects. Hum Reprod Update. 2001;7:603–610. doi: 10.1093/humupd/7.6.603. - DOI - PubMed
    1. Grimbizis GF, Camus M, Tarlatzis BC, Bontis JN, Devroey P. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update. 2001;7:161–174. doi: 10.1093/humupd/7.2.161. - DOI - PubMed
    1. Bakalov VK, Shawker T, Ceniceros I, Bondy CA. Uterine development in Turner syndrome. J Pediatr. 2007;151:528–31, 531. doi: 10.1016/j.jpeds.2007.04.031. - DOI - PMC - PubMed