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Comparative Study
. 2019 Jul 10;20(1):145.
doi: 10.1186/s12931-019-1111-1.

Do blood eosinophils strictly reflect airway inflammation in COPD? Comparison with asthmatic patients

Patrizia Pignatti  1 , Dina Visca  2 , Francesca Cherubino  3 , Elisabetta Zampogna  3 , Etienne Lucini  3 , Laura Saderi  4 , Giovanni Sotgiu  4 , Antonio Spanevello  2
Affiliations
Comparative Study

Do blood eosinophils strictly reflect airway inflammation in COPD? Comparison with asthmatic patients

Patrizia Pignatti et al. Respir Res. .

Abstract

Introduction: Airway eosinophilic inflammation is a characteristic of asthmatic patients and of a sub group of COPD subjects. Blood eosinophils are deemed as a good surrogate marker of sputum eosinophilic inflammation; however, controversial data have been published particularly in COPD. The aim of our study was to compare blood and sputum eosinophils in COPD and asthmatic patients in "real life".

Methods: Sputum was induced in stable patients with COPD or asthma with hypertonic saline solution and blood eosinophils were evaluated. Frequency of comorbidities was recorded. Correlations were performed stratifying patients by disease and comorbidities.

Results: 146 patients, 57 with COPD and 89 with asthma were evaluated. Blood and sputum eosinophils expressed as percentages were correlated in COPD (rho = 0.40; p = 0.004), but the entity of correlation was lower compared with asthmatic subjects (rho = 0.71; p < 0.0001). When blood eosinophils were expressed as counts the correlation was slightly lower than when expressed as percentages in COPD (rho = 0.35; p = 0.01) and in asthmatic patients (rho = 0.68; p < 0.0001). In COPD patients older than 73 years or with blood eosinophils higher than the median value (210.6 eos/μl), or co-diagnosed with hypertension, ischemic heart disease or atrial fibrillation no correlation between blood and sputum eosinophils was found. However, the effect of ischemic heart disease and atrial fibrillation could be driven by hypertension since most of these patients have this comorbidity.

Conclusion: Blood eosinophils correlated with sputum eosinophils to a lesser degree in COPD than in asthmatic patients. Older age, high blood eosinophils and hypertension affected the correlation between blood and sputum eosinophils, more studies are needed to evaluate the role of other cardiac comobidities.

Keywords: Airway inflammation; Asthma; COPD; Correlation; Eosinophils; Sputum.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Correlation between sputum and blood eosinophils expressed as percentage (a-b) or absolute count (c-d) in COPD (a-c) and asthma (b-d)
Fig. 2
Fig. 2
Correlation between sputum and blood eosinophils expressed as percentage in COPD patients with (circles) and without hypertension (triangles)
See this image and copyright information in PMC

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