"Does the opioid system block or enhance the antidepressant effects of ketamine?"

doi:10.1177/2470547019852073

Comment

. 2019:3:2470547019852073.

doi: 10.1177/2470547019852073. Epub 2019 Jun 16.

"Does the opioid system block or enhance the antidepressant effects of ketamine?"

Sanjay J Mathew^{1

2}, Ana Maria Rivas-Grajales^{1

2}

Affiliations

¹ Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA.
² Michael E. Debakey VA Medical Center, Houston, TX, USA.

PMID: 31276079
PMCID: PMC6604658
DOI: 10.1177/2470547019852073

Comment

"Does the opioid system block or enhance the antidepressant effects of ketamine?"

Sanjay J Mathew et al. Chronic Stress (Thousand Oaks). 2019.

. 2019:3:2470547019852073.

doi: 10.1177/2470547019852073. Epub 2019 Jun 16.

Authors

Sanjay J Mathew^{1

2}, Ana Maria Rivas-Grajales^{1

2}

Affiliations

¹ Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA.
² Michael E. Debakey VA Medical Center, Houston, TX, USA.

PMID: 31276079
PMCID: PMC6604658
DOI: 10.1177/2470547019852073

No abstract available

Keywords: antidepressant; depression; ketamine; naltrexone; opioid.

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Conflict of interest statement

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr Mathew has received consulting fees from Alkermes, Allergan, Bracket, Clexio Biosciences, Janssen, Perception Neurosciences, and Sage Therapeutics. He has received research support from Biohaven Pharmaceuticals and VistaGen Therapeutics.

Comment on

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.
Williams NR, Heifets BD, Blasey C, Sudheimer K, Pannu J, Pankow H, Hawkins J, Birnbaum J, Lyons DM, Rodriguez CI, Schatzberg AF. Williams NR, et al. Am J Psychiatry. 2018 Dec 1;175(12):1205-1215. doi: 10.1176/appi.ajp.2018.18020138. Epub 2018 Aug 29. Am J Psychiatry. 2018. PMID: 30153752 Free PMC article. Clinical Trial.
Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder.
Yoon G, Petrakis IL, Krystal JH. Yoon G, et al. JAMA Psychiatry. 2019 Mar 1;76(3):337-338. doi: 10.1001/jamapsychiatry.2018.3990. JAMA Psychiatry. 2019. PMID: 30624551 Free PMC article. Clinical Trial.

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Ketamine: The final frontier or another depressing end?
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Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.
Kokane SS, Armant RJ, Bolaños-Guzmán CA, Perrotti LI. Kokane SS, et al. Behav Brain Res. 2020 Apr 20;384:112548. doi: 10.1016/j.bbr.2020.112548. Epub 2020 Feb 13. Behav Brain Res. 2020. PMID: 32061748 Free PMC article. Review.
Ketamine: A tale of two enantiomers.
Jelen LA, Young AH, Stone JM. Jelen LA, et al. J Psychopharmacol. 2021 Feb;35(2):109-123. doi: 10.1177/0269881120959644. Epub 2020 Nov 6. J Psychopharmacol. 2021. PMID: 33155503 Free PMC article. Review.

References

1. Zanos P, Gould TD. Mechanisms of ketamine action as an antidepressant. Mol Psychiatry. 2018; 23(4): 801–811. - PMC - PubMed
1. Moda-Sava RN, Murdock MH, Parekh PK, et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 2019; 354(6435): eaat8078. - PMC - PubMed
1. Williams NR, Heifets BD, Blasey C, et al. Attenuation of antagonism effects of ketamine by opioid receptor antagonism. Am J Psychiatry. 2018; 175(12): 1205–1215. - PMC - PubMed
1. Rorick-Kehn LM, Witcher JW, Lowe SL, et al. Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. Int J Neuropsychopharmacology. 2015; 18(2): 1–11. - PMC - PubMed
1. Zhang K, Hashimoto K. Lack of opioid system in the antidepressant actions of ketamine. Biol Psychiatry. 2019; 85: e25–e27. - PubMed

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[1] Zanos P, Gould TD. Mechanisms of ketamine action as an antidepressant. Mol Psychiatry. 2018; 23(4): 801–811. - PMC - PubMed

[2] Zanos P, Gould TD. Mechanisms of ketamine action as an antidepressant. Mol Psychiatry. 2018; 23(4): 801–811. - PMC - PubMed

[3] Moda-Sava RN, Murdock MH, Parekh PK, et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 2019; 354(6435): eaat8078. - PMC - PubMed

[4] Moda-Sava RN, Murdock MH, Parekh PK, et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 2019; 354(6435): eaat8078. - PMC - PubMed

[5] Williams NR, Heifets BD, Blasey C, et al. Attenuation of antagonism effects of ketamine by opioid receptor antagonism. Am J Psychiatry. 2018; 175(12): 1205–1215. - PMC - PubMed

[6] Williams NR, Heifets BD, Blasey C, et al. Attenuation of antagonism effects of ketamine by opioid receptor antagonism. Am J Psychiatry. 2018; 175(12): 1205–1215. - PMC - PubMed

[7] Rorick-Kehn LM, Witcher JW, Lowe SL, et al. Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. Int J Neuropsychopharmacology. 2015; 18(2): 1–11. - PMC - PubMed

[8] Rorick-Kehn LM, Witcher JW, Lowe SL, et al. Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. Int J Neuropsychopharmacology. 2015; 18(2): 1–11. - PMC - PubMed

[9] Zhang K, Hashimoto K. Lack of opioid system in the antidepressant actions of ketamine. Biol Psychiatry. 2019; 85: e25–e27. - PubMed

[10] Zhang K, Hashimoto K. Lack of opioid system in the antidepressant actions of ketamine. Biol Psychiatry. 2019; 85: e25–e27. - PubMed

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"Does the opioid system block or enhance the antidepressant effects of ketamine?"

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"Does the opioid system block or enhance the antidepressant effects of ketamine?"

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