Review
doi: 10.1038/332040a0.
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens
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- PMID: 3126397
- DOI: 10.1038/332040a0
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Review
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens
Nature.
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Abstract
T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.
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