Review
doi: 10.1038/332035a0.
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
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- PMID: 3126396
- DOI: 10.1038/332035a0
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Review
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
Nature.
.
Abstract
In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell alpha/beta receptor repertoire, including nearly all receptors that use V beta 8.1. The presence of Mlsa/MHC during T-cell development results in the deletion of T cells that express V beta 8.1, documenting the importance of clonal deletion in establishing tolerance to self antigens.
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