Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May 8:2019:1484152.
doi: 10.1155/2019/1484152. eCollection 2019.

Modulated Autophagy by MicroRNAs in Osteoarthritis Chondrocytes

Yinghao Yu  1 , Jijun Zhao  1
Affiliations
Review

Modulated Autophagy by MicroRNAs in Osteoarthritis Chondrocytes

Yinghao Yu et al. Biomed Res Int. .

Abstract

Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage regression. The etiology of OA is diverse, the exact pathogenesis of which remains unclear. Autophagy is a conserved maintenance mechanism in eukaryotic cells. Dysfunction of chondrocyte autophagy is regarded as a crucial pathogenesis of cartilage degradation in OA. MircoRNAs (miRNAs) are a category of small noncoding RNAs, acting as posttranscriptional modulators that regulate biological processes and cell signaling pathways via target genes. A series of miRNAs are involved in the progression of chondrocyte autophagy and are connected with numerous factors and pathways. This article focuses on the mechanisms of chondrocyte autophagy in OA and reviews the role of miRNA in their modulation. Potentially relevant miRNAs are also discussed in order to provide new directions for future research and improve our understanding of the autophagic network of miRNAs.

PubMed Disclaimer

Figures

Figure 1
Figure 1
miRNAs, specific targets and signaling pathways in the process of chondrocyte autophagy in OA. Note: miRNAs highlighted in red represent confirmed mechanisms while those highlighted in blue represent hypothesized mechanisms.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. D’Adamo S., Cetrullo S., Minguzzi M., et al. MicroRNAs and autophagy: fine players in the control of chondrocyte homeostatic activities in osteoarthritis. Oxidative Medicine and Cellular Longevity. 2017;2017:16. doi: 10.1155/2017/3720128.3720128 - DOI - PMC - PubMed
    1. Temple M. M., Bae W. C., Chen M. Q., et al. Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle. Osteoarthritis and Cartilage. 2007;15(9):1042–1052. doi: 10.1016/j.joca.2007.03.005. - DOI - PubMed
    1. Blagojevic M., Jinks C., Jeffery A., Jordan K. P. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis and Cartilage. 2010;18(1):24–33. doi: 10.1016/j.joca.2009.08.010. - DOI - PubMed
    1. Bijlsma J. W. J., Berenbaum F., Lafeber F. P. J. G. Osteoarthritis: an update with relevance for clinical practice. The Lancet. 2011;377(9783):2115–2126. doi: 10.1016/s0140-6736(11)60243-2. - DOI - PubMed
    1. Endisha H., Rockel J., Jurisica I., Kapoor M. The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets. JCI Insight. 2018;3(17) doi: 10.1172/jci.insight.121630.e121630 - DOI - PMC - PubMed