A brief history of artemisinin: Modes of action and mechanisms of resistance

doi:10.1016/S1875-5364(19)30038-X

Review

. 2019 May 20;17(5):331-336.

doi: 10.1016/S1875-5364(19)30038-X.

A brief history of artemisinin: Modes of action and mechanisms of resistance

Feng Lu¹, Xin-Long He², Culleton Richard³, Jun Cao⁴

Affiliations

¹ Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China; Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
² Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China.
³ Malaria Unit, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan. Electronic address: richard@nagasakiu.ac.jp.
⁴ Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Public Health Research Center, Jiangnan University, Wuxi 214122, China. Electronic address: caojuncn@hotmail.com.

PMID: 31171267
DOI: 10.1016/S1875-5364(19)30038-X

Review

A brief history of artemisinin: Modes of action and mechanisms of resistance

Feng Lu et al. Chin J Nat Med. 2019.

. 2019 May 20;17(5):331-336.

doi: 10.1016/S1875-5364(19)30038-X.

Authors

Feng Lu¹, Xin-Long He², Culleton Richard³, Jun Cao⁴

Affiliations

¹ Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China; Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
² Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China.
³ Malaria Unit, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan. Electronic address: richard@nagasakiu.ac.jp.
⁴ Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Public Health Research Center, Jiangnan University, Wuxi 214122, China. Electronic address: caojuncn@hotmail.com.

PMID: 31171267
DOI: 10.1016/S1875-5364(19)30038-X

Abstract

The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced sensitivity to artemisinin have emerged, and this threatens malaria control and elimination efforts. In this minireview, we describe the initial development of artemisinin as an antimalarial drug, its use both historically and currently, and our current understanding of its mode of action and the mechanisms by which malaria parasites achieve resistance.

Keywords: Artemisinin; Malaria; Resistance.

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A brief history of artemisinin: Modes of action and mechanisms of resistance

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A brief history of artemisinin: Modes of action and mechanisms of resistance

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