Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017

doi:10.1080/14786419.2019.1610757

. 2021 Mar;35(6):900-908.

doi: 10.1080/14786419.2019.1610757. Epub 2019 May 31.

Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017

Limbadri Salendra^{1

2}, Xiuping Lin¹, Weihao Chen^{1

2}, Xiaoyan Pang³, Xiaowei Luo^{1

2}, Jieyi Long^{1

2}, Shengrong Liao¹, Junfeng Wang¹, Xuefeng Zhou¹, Yonghong Liu^{1

2

4}, Bin Yang¹

Affiliations

¹ Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, China.
⁴ Institution of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, Guangzhou, China.

PMID: 31148464
DOI: 10.1080/14786419.2019.1610757

Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017

Limbadri Salendra et al. Nat Prod Res. 2021 Mar.

. 2021 Mar;35(6):900-908.

doi: 10.1080/14786419.2019.1610757. Epub 2019 May 31.

Authors

Affiliations

¹ Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, China.
⁴ Institution of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, Guangzhou, China.

PMID: 31148464
DOI: 10.1080/14786419.2019.1610757

Abstract

Two new polyketides, xerucitrinin A (1) and coniochaetone M (8), and one new steroid, 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (13), together with eleven known analogues were isolated from fungus Penicillium citrinum SCSIO 41017 associated with the sponge Callyspongia sp. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that 5 exhibited significant cytotoxic activity against MCF-7 cell line with IC₅₀ values of 1.3 μM. Compound 13 showed moderate activity against all cell lines with IC₅₀ values of 13.5-18.0 μM, and compounds 9 and 14 showed weak activity with MIC values of ranging from 125 μg/mL to 250 μg/mL respectively.[Formula: see text].

Keywords: Penicillium citrinum SCSIO 41017; Sponge-associated fungus; cytotoxicity; polyketides; steroids.

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Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017

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Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017

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