Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling

doi:10.1007/s11427-018-9488-1

Review

. 2019 Oct;62(10):1368-1374.

doi: 10.1007/s11427-018-9488-1. Epub 2019 May 14.

Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling

Jian Li¹, Yun Zou^{1

2}, Zhifang Li^{1

2}, Yaming Jiu^{3

4}

Affiliations

¹ CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China. ymjiu@ips.ac.cn.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. ymjiu@ips.ac.cn.

PMID: 31098891
DOI: 10.1007/s11427-018-9488-1

Review

Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling

Jian Li et al. Sci China Life Sci. 2019 Oct.

. 2019 Oct;62(10):1368-1374.

doi: 10.1007/s11427-018-9488-1. Epub 2019 May 14.

Authors

Jian Li¹, Yun Zou^{1

2}, Zhifang Li^{1

2}, Yaming Jiu^{3

4}

Affiliations

¹ CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China. ymjiu@ips.ac.cn.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. ymjiu@ips.ac.cn.

PMID: 31098891
DOI: 10.1007/s11427-018-9488-1

Abstract

Many key cellular functions are regulated by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments (IFs), which is a hitherto poorly investigated area of research. However, there are growing evidence in the last few years showing that the IFs cooperate with actin filaments to exhibit strongly coupled functions. This review recapitulates our current knowledge on how the crosstalk between IFs and actin filaments modulates the migration properties, mechano-responsiveness and signaling transduction of cells, from both biophysical and biochemical point of view.

Keywords: actin; cell mechanosensing; cell migration; cytoskeletal interaction; intermediate filaments; signaling pathway.

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Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling

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Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling

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