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. 2019:114:e180443.
doi: 10.1590/0074-02760180443. Epub 2019 May 13.

Mycobacterium genus and tRNA arrays

Sergio Mascarenhas Morgado  1 , Ana Carolina Paulo Vicente  1
Affiliations

Mycobacterium genus and tRNA arrays

Sergio Mascarenhas Morgado et al. Mem Inst Oswaldo Cruz. 2019.

Abstract

The presence of tRNA array, a region with high tRNA gene number and density, has been demonstrated in Mycobacterium genus. However, a recent phylogenomic study revealed the existence of five distinct monophyletic groups (genera) within this genus. Considering this new scenario, and based on in-silico analyses, we have identified and characterised the abundance and diversity of tRNA array units within Mycobacterium, Mycolicibacterium gen. nov., Mycolicibacillus gen. nov., and Mycobacteroides gen. nov. The occurrence and prevalence of tRNA arrays among the genera belonging to Actinobacteria indicate their possible role in the organismal fitness.

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Figures

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Phylogenetic tree of Mycobacterium, Mycolicibacterium gen. nov., Mycolicibacter gen. nov., Mycolicibacillus gen. nov., and Mycobacteroides gen. nov. (left side). The genera are discriminated by the background colour and the dotted branches correspond to the slow-growing species. The genomes highlighted in bold represent those with an increase in the isoacceptor species. The symbols indicate tRNA array group: circle, group 1; square, group 2; star, group 3; triangle, singleton. The tRNA isotype organisation of each array is represented using the single-letter amino acid code (right side). The isotypes in bold correspond to the genes annotated as pseudogenes.
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