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. 2019 Apr 22;9(2):e18.
doi: 10.5415/apallergy.2019.9.e18. eCollection 2019 Apr.

Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy

Joan Nakata  1 , Tatsuhiko Hirota  2 , Harue Umemura  1 , Tomoko Nakagawa  1 , Naoyuki Kando  1 , Masaki Futamura  3 , Yasunori Nakamura  2 , Komei Ito  1
Affiliations

Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy

Joan Nakata et al. Asia Pac Allergy. .

Abstract

Background: Atopic dermatitis (AD) in infants is often related to food allergies (FA). The beneficial effects of lactic acid bacteria towards allergic diseases have been reported, but there are few reports on their effect and preferable dosages on AD in young children with concomitant FA.

Objective: To examine additional effects of two different dose of paraprobiotic Lactobacillus acidophilus L-92 (L-92) on the clinical treatment in young children afflicted by AD with diagnosed or suspected FA.

Methods: Fifty-nine AD young children from 10 months to 3 years old, with FA or who had not started to ingest specific food(s) because of high specific IgE levels, were recruited and randomly allocated into L-92 group (daily intake of 20 mg L-92/day) and placebo group. Participants were given test sample with conventional treatment for AD over a 24-week period. The severity of eczema was evaluated using SCORing Atopic Dermatitis (SCORAD) index before intervention, and at 4, 12, and 24 weeks after intervention.

Results: After 24 weeks of intervention, a significant decrease in SCORAD was observed only in the L-92 group when compared with the baseline values. Significant decreases in thymus and activation-regulated chemokine (TARC) and total IgE were also detected 24 weeks after intake in the L-92 group compared with the placebo group.

Conclusion: It was suggested that intake of sufficient amounts of L-92 works as an adjunctive treatment of young children afflicted by AD with diagnosed or suspected FA.

Keywords: Atopic dermatitis; Food sensitivity; Lactobacillus acidophilus.

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Conflict of interest statement

Conflict of Interest: The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1. Enrollment of participants.
Fig. 2
Fig. 2. Changes in SCORing Atopic Dermatitis (SCORAD). (A) Changes in SCORAD between visits 1 and 4. Broken lines represent individual data. Wilcoxon signed-rank test was used for a comparison between visits 1 and 4. (B) Boxplots of SCORAD. Open circles (○) represent outliers. Mann-Whitney test was used for a comparison between groups. *p < 0.05. **p < 0.01.
Fig. 3
Fig. 3. Changes in the intestinal bacterial flora. The viable cell counts of Enterobacteriaceae (A), lecithinase (-) Clostridium (B), and Lactobacillus (C) in each group at visits 1 and 4 are shown. Data are expressed as the mean ± standard error. **p < 0.01 using the paired t test.
Fig. 4
Fig. 4. Infants' Dermatitis Quality of Life index (IDQOL). IDQOL scores for each group at visits 1 and 4 are shown. *p < 0.05 using the Mann-Whitney test for between groups, and Wilcoxon signed-rank test for a before-and-after comparative analysis.
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