Molecular Basis for Arbovirus Transmission by Aedes aegypti Mosquitoes
- PMID: 31082816
- DOI: 10.1159/000499128
Molecular Basis for Arbovirus Transmission by Aedes aegypti Mosquitoes
Abstract
Mosquitoes are considered the most important vectors for the transmission of pathogens to humans. Aedes aegypti is a unique species, not only by its highly anthropophilic and peridomestic habits but also because it can transmit an important variety of pathogenic viruses. Examples are dengue, yellow fever, chikungunya, Zika, and Mayaro viruses. After ingesting viremic blood, a wide range of mechanisms are activated in the mosquito to counteract viral infection. Nevertheless, these arboviruses possess strategies to overcome barriers in the mosquito and eventually reach the salivary glands to continue the transmission cycle. However, the infection and eventual transmission of arbovirus depends on multiple factors. The current review focuses in detail on the anatomic, physiological, and molecular characteristics of the mosquito A. aegypti that participate in response to a viral infection. In the past decades, the awareness of the importance of this mosquito as a disease vector and its impact on human health was largely recognized. We need to improve our comprehension of molecular mechanisms that determine the outcome of successful virus replication or control of infection for each arbovirus in the vector; this could lead to the design of effective control strategies in the future.
Keywords: Aedes aegypti; Arbovirus; Determinants; Mosquitoes; Transmission.
© 2019 S. Karger AG, Basel.
Similar articles
-
Cell-Fusing Agent Virus Reduces Arbovirus Dissemination in Aedes aegypti Mosquitoes In Vivo.J Virol. 2019 Aug 28;93(18):e00705-19. doi: 10.1128/JVI.00705-19. Print 2019 Sep 15. J Virol. 2019. PMID: 31243123 Free PMC article.
-
The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.PLoS Pathog. 2020 Dec 22;16(12):e1009134. doi: 10.1371/journal.ppat.1009134. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33351855 Free PMC article.
-
How Do Virus-Mosquito Interactions Lead to Viral Emergence?Trends Parasitol. 2018 Apr;34(4):310-321. doi: 10.1016/j.pt.2017.12.004. Epub 2018 Jan 2. Trends Parasitol. 2018. PMID: 29305089 Free PMC article. Review.
-
Vertebrate-Aedes aegypti and Culex quinquefasciatus (Diptera)-arbovirus transmission networks: Non-human feeding revealed by meta-barcoding and next-generation sequencing.PLoS Negl Trop Dis. 2020 Dec 31;14(12):e0008867. doi: 10.1371/journal.pntd.0008867. eCollection 2020 Dec. PLoS Negl Trop Dis. 2020. PMID: 33382725 Free PMC article.
-
Aedes-Borne Virus-Mosquito Interactions: Mass Spectrometry Strategies and Findings.Vector Borne Zoonotic Dis. 2017 Jun;17(6):361-375. doi: 10.1089/vbz.2016.2040. Epub 2017 Feb 13. Vector Borne Zoonotic Dis. 2017. PMID: 28192064 Review.
Cited by
-
Transcriptome Analysis of Responses to Dengue Virus 2 Infection in Aedes albopictus (Skuse) C6/36 Cells.Viruses. 2021 Feb 22;13(2):343. doi: 10.3390/v13020343. Viruses. 2021. PMID: 33671824 Free PMC article.
-
Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission?Parasit Vectors. 2022 Aug 9;15(1):287. doi: 10.1186/s13071-022-05401-9. Parasit Vectors. 2022. PMID: 35945559 Free PMC article. Review.
-
Acute Chikungunya Virus Infection Triggers a Diverse Range of T Helper Lymphocyte Profiles.Viruses. 2024 Aug 30;16(9):1387. doi: 10.3390/v16091387. Viruses. 2024. PMID: 39339863 Free PMC article.
-
Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication.Pathogens. 2020 Feb 25;9(3):158. doi: 10.3390/pathogens9030158. Pathogens. 2020. PMID: 32106582 Free PMC article. Review.
-
Longitudinal Study of Viral Diversity Associated with Mosquito Species Circulating in Cambodia.Viruses. 2023 Aug 29;15(9):1831. doi: 10.3390/v15091831. Viruses. 2023. PMID: 37766237 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
