A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides

doi:10.1016/j.carbpol.2019.04.025

Review

. 2019 Aug 1:217:79-89.

doi: 10.1016/j.carbpol.2019.04.025. Epub 2019 Apr 20.

A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides

Yalda Rahbar Saadat¹, Ahmad Yari Khosroushahi², Bahram Pourghassem Gargari³

Affiliations

¹ Nutrition Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yalda.saadat@gmail.com.
² Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yarikhosroushahia@tbzmed.ac.ir.
³ Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: bahrampg@yahoo.com.

PMID: 31079688
DOI: 10.1016/j.carbpol.2019.04.025

Review

A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides

Yalda Rahbar Saadat et al. Carbohydr Polym. 2019.

. 2019 Aug 1:217:79-89.

doi: 10.1016/j.carbpol.2019.04.025. Epub 2019 Apr 20.

Authors

Yalda Rahbar Saadat¹, Ahmad Yari Khosroushahi², Bahram Pourghassem Gargari³

Affiliations

¹ Nutrition Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yalda.saadat@gmail.com.
² Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yarikhosroushahia@tbzmed.ac.ir.
³ Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: bahrampg@yahoo.com.

PMID: 31079688
DOI: 10.1016/j.carbpol.2019.04.025

Abstract

Several scientific evidences have revealed probiotics implications on human health. A wide range of lactic acid bacteria (LAB) have been extensively studied for their ability to produce extracellular polysaccharides (EPSs), which are repeating units of mono/oligosaccharides with various chemical compositions and properties. Despite the conventional belief regarding probiotics that states bacteria must be alive to exert their beneficial effects, mounting evidence opened up new perspectives on health-promoting effects of bacterial-derived molecules/metabolites. Employing EPSs seems safer alternative in complicated disorders like cancer and immune related diseases. EPSs have potential applications in textiles, cosmetology, wastewater treatment, food, and pharmaceutical industries, but little is known about their function therefore the present review aims to discuss the health-promoting properties of EPSs produced by LAB. Antioxidant, antiviral, antitumor and immunomodulating activity, with focus on the mechanisms involved, are discussed in the study. Ever-growing number of researches indicate that EPSs beneficiary effects have a promising future ahead.

Keywords: Anti-cancer; Antioxidant; Exopolysaccharides; Immunomodulation; Probiotics.

PubMed Disclaimer

Cited by

The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins.
Poluektova E, Yunes R, Danilenko V. Poluektova E, et al. Nutrients. 2021 May 10;13(5):1591. doi: 10.3390/nu13051591. Nutrients. 2021. PMID: 34068669 Free PMC article. Review.
Characterization of Novel Exopolysaccharides from Enterococcus hirae WEHI01 and Its Immunomodulatory Activity.
Jia K, Wei M, He Y, Wang Y, Wei H, Tao X. Jia K, et al. Foods. 2022 Nov 7;11(21):3538. doi: 10.3390/foods11213538. Foods. 2022. PMID: 36360150 Free PMC article.
The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences? A systematic review.
Ranjbar M, Salehi R, Haghjooy Javanmard S, Rafiee L, Faraji H, Jafarpor S, Ferns GA, Ghayour-Mobarhan M, Manian M, Nedaeinia R. Ranjbar M, et al. Cancer Cell Int. 2021 Apr 6;21(1):194. doi: 10.1186/s12935-021-01886-z. Cancer Cell Int. 2021. PMID: 33823861 Free PMC article. Review.
Influence of Three Extraction Methods on the Physicochemical Properties of Kefirans Isolated from Three Types of Animal Milk.
La Torre C, Fazio A, Caputo P, Tursi A, Formoso P, Cione E. La Torre C, et al. Foods. 2022 Apr 12;11(8):1098. doi: 10.3390/foods11081098. Foods. 2022. PMID: 35454685 Free PMC article.
Anti-Helicobacter pylori Activity of a Lactobacillus sp. PW-7 Exopolysaccharide.
Hu J, Tian X, Wei T, Wu H, Lu J, Lyu M, Wang S. Hu J, et al. Foods. 2021 Oct 14;10(10):2453. doi: 10.3390/foods10102453. Foods. 2021. PMID: 34681500 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Substances

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- The Lens - Patent Citations Database
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides

Affiliations

A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous