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. 1987 Mar;60(3):389-93.

T-cell activation by anti-idiotypic antibody: evidence for the internal image

A D Rees, K Praputpittaya, A Scoging, N Dobson, J Ivanyi, D Young, J R Lamb

T-cell activation by anti-idiotypic antibody: evidence for the internal image

A D Rees et al. Immunology. 1987 Mar.

Abstract

Human lymphoproliferative responses to a rabbit anti-idiotypic antibody (anti-Id TB71) and the corresponding mycobacterial protein antigen [38,000 molecular weight (MW)] have been investigated in a number of donors. It was found that responsiveness to anti-Id TB71 correlated with responder and non-responder (four subjects each) status to the 38,000 MW antigen. Furthermore, the induction of T-cell proliferation by both the 38,000 MW antigen and the anti-Id TB71 was dependent on accessory cells. When taken together with the concordance between the 38,000 MW antigen and anti-Id responsiveness, this implies that the 38,000 MW antigen and anti-Id TB71 stimulate related, or at least partially overlapping, repertoires of T cells. This was confirmed by the finding that cloned T cells reactive with the 38,000 MW antigen also proliferated in response to the anti-Id TB71. These observations are readily explained if the anti-idiotypic antibody contains an internal image of, and can therefore mimic, the antigen.

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References

    1. Proc Natl Acad Sci U S A. 1978 May;75(5):2443-7 - PubMed
    1. Eur J Immunol. 1973 Oct;3(10):645-9 - PubMed
    1. Contemp Top Mol Immunol. 1981;8:113-48 - PubMed
    1. Lancet. 1981 Jul 25;2(8239):167-9 - PubMed
    1. J Immunol. 1982 Jan;128(1):233-8 - PubMed

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