Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment

doi:10.3389/fnins.2019.00355

. 2019 Apr 17:13:355.

doi: 10.3389/fnins.2019.00355. eCollection 2019.

Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment

Jiaen Ye¹, Feng Ji², Deguo Jiang³, Xiaodong Lin¹, Guangdong Chen¹, Wei Zhang¹, Peiwei Shan¹, Li Zhang⁴, Chuanjun Zhuo^{1

2

3}

Affiliations

¹ Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, China.
² Department of Psychiatry, College of Mental Health, Jining Medical University, Jining, China.
³ Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory (PNGC-Lab), Nankai University Affiliated Tianjin Anding Hospital, Tianjin Mental Health Center, Mental Health Teaching Hospital, Tianjin Medical University, Tianjin, China.
⁴ GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China.

PMID: 31057354
PMCID: PMC6479209
DOI: 10.3389/fnins.2019.00355

Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment

Jiaen Ye et al. Front Neurosci. 2019.

. 2019 Apr 17:13:355.

doi: 10.3389/fnins.2019.00355. eCollection 2019.

Authors

Jiaen Ye¹, Feng Ji², Deguo Jiang³, Xiaodong Lin¹, Guangdong Chen¹, Wei Zhang¹, Peiwei Shan¹, Li Zhang⁴, Chuanjun Zhuo^{1

2

3}

Affiliations

¹ Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, China.
² Department of Psychiatry, College of Mental Health, Jining Medical University, Jining, China.
³ Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory (PNGC-Lab), Nankai University Affiliated Tianjin Anding Hospital, Tianjin Mental Health Center, Mental Health Teaching Hospital, Tianjin Medical University, Tianjin, China.
⁴ GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China.

PMID: 31057354
PMCID: PMC6479209
DOI: 10.3389/fnins.2019.00355

Abstract

Dopaminergic system dysfunction is involved in schizophrenia (SCZ) pathogenesis and can mediate SCZ-related motor disorders. Recent studies have gradually revealed that SCZ susceptibility and the associated motor symptoms can be mediated by genetic factors, including dopaminergic genes. More importantly, polymorphisms in these genes are associated with both antipsychotic drug sensitivity and adverse effects. The study of genetic polymorphisms in the dopaminergic system may help to optimize individualized drug strategies for SCZ patients. This review summarizes the current progress about the involvement of the dopamine system in SCZ-associated motor disorders and the motor-related adverse effects after antipsychotic treatment, with a special focus on polymorphisms in dopaminergic genes. We hypothesize that the genetic profile of the dopaminergic system mediates both SCZ-associated motor deficits associated and antipsychotic drug-related adverse effects. The study of dopaminergic gene polymorphisms may help to predict drug efficacy and decrease adverse effects, thereby optimizing treatment strategies.

Keywords: antipsychotic drugs; dopaminergic transmission; gene polymorphism; pharmacogenetics; schizophrenia.

PubMed Disclaimer

Figures

**Figure 1**
Current working model for regulation of dopaminergic system and the effect of genetic polymorphism on motor dysfunction and antipsychotic drug-related motor deficits in SCZ patients.

See this image and copyright information in PMC

Cited by

Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease.
Chen APF, Chen L, Kim TA, Xiong Q. Chen APF, et al. Biomedicines. 2021 Jun 7;9(6):647. doi: 10.3390/biomedicines9060647. Biomedicines. 2021. PMID: 34200134 Free PMC article. Review.
Characterization of neural mechanotransduction response in human traumatic brain injury organoid model.
Beltrán SM, Bobo J, Habib A, Kodavali CV, Edwards L, Mamindla P, Taylor RE, LeDuc PR, Zinn PO. Beltrán SM, et al. Sci Rep. 2023 Aug 19;13(1):13536. doi: 10.1038/s41598-023-40431-y. Sci Rep. 2023. PMID: 37598247 Free PMC article.
Association of DRD2, DRD4 and COMT genes variants and their gene-gene interactions with antipsychotic treatment response in patients with schizophrenia.
Taheri N, Pirboveiri R, Sayyah M, Bijanzadeh M, Ghandil P. Taheri N, et al. BMC Psychiatry. 2023 Oct 25;23(1):781. doi: 10.1186/s12888-023-05292-9. BMC Psychiatry. 2023. PMID: 37880658 Free PMC article.
The Role of Dopamine D3 Receptors, Dysbindin, and Their Functional Interaction in the Expression of Key Genes for Neuroplasticity and Neuroinflammation in the Mouse Brain.
Rivi V, Benatti C, Blom JMC, Pani L, Brunello N, Drago F, Papaleo F, Caraci F, Geraci F, Torrisi SA, Leggio GM, Tascedda F. Rivi V, et al. Int J Mol Sci. 2023 May 12;24(10):8699. doi: 10.3390/ijms24108699. Int J Mol Sci. 2023. PMID: 37240042 Free PMC article.

References

1. Abboud R., Noronha C., Diwadkar V. A. (2017). Motor system dysfunction in the schizophrenia diathesis: neural systems to neurotransmitters. Eur. Psychiatry 44, 125–133. 10.1016/j.eurpsy.2017.04.004 - DOI - PMC - PubMed
1. Abi-Dargham A. (2014). Dopamine dysfunction in schizophrenia. Schizophr. Res. 160, e6–e7. 10.1016/j.schres.2014.09.069 - DOI
1. Bernagie C., Danckaerts M., Wampers M., De Hert M. (2016). Aripiprazole and acute extrapyramidal symptoms in children and adolescents: a meta-analysis. CNS Drugs 30, 807–818. 10.1007/s40263-016-0367-y - DOI - PMC - PubMed
1. Bilic P., Jukic V., Vilibic M., Savic A., Bozina N. (2014). Treatment-resistant schizophrenia and DAT and SERT polymorphisms. Gene 543, 125–132. 10.1016/j.gene.2014.03.050 - DOI - PubMed
1. Birnbaum R., Weinberger D. R. (2017). Genetic insights into the neurodevelopmental origins of schizophrenia. Nat. Rev. Neurosci. 18, 727–740. 10.1038/nrn.2017.125 - DOI - PubMed

LinkOut - more resources

Full Text Sources

[1] Abboud R., Noronha C., Diwadkar V. A. (2017). Motor system dysfunction in the schizophrenia diathesis: neural systems to neurotransmitters. Eur. Psychiatry 44, 125–133. 10.1016/j.eurpsy.2017.04.004 - DOI - PMC - PubMed

[2] Abboud R., Noronha C., Diwadkar V. A. (2017). Motor system dysfunction in the schizophrenia diathesis: neural systems to neurotransmitters. Eur. Psychiatry 44, 125–133. 10.1016/j.eurpsy.2017.04.004 - DOI - PMC - PubMed

[3] Abi-Dargham A. (2014). Dopamine dysfunction in schizophrenia. Schizophr. Res. 160, e6–e7. 10.1016/j.schres.2014.09.069 - DOI

[4] Abi-Dargham A. (2014). Dopamine dysfunction in schizophrenia. Schizophr. Res. 160, e6–e7. 10.1016/j.schres.2014.09.069 - DOI

[5] Bernagie C., Danckaerts M., Wampers M., De Hert M. (2016). Aripiprazole and acute extrapyramidal symptoms in children and adolescents: a meta-analysis. CNS Drugs 30, 807–818. 10.1007/s40263-016-0367-y - DOI - PMC - PubMed

[6] Bernagie C., Danckaerts M., Wampers M., De Hert M. (2016). Aripiprazole and acute extrapyramidal symptoms in children and adolescents: a meta-analysis. CNS Drugs 30, 807–818. 10.1007/s40263-016-0367-y - DOI - PMC - PubMed

[7] Bilic P., Jukic V., Vilibic M., Savic A., Bozina N. (2014). Treatment-resistant schizophrenia and DAT and SERT polymorphisms. Gene 543, 125–132. 10.1016/j.gene.2014.03.050 - DOI - PubMed

[8] Bilic P., Jukic V., Vilibic M., Savic A., Bozina N. (2014). Treatment-resistant schizophrenia and DAT and SERT polymorphisms. Gene 543, 125–132. 10.1016/j.gene.2014.03.050 - DOI - PubMed

[9] Birnbaum R., Weinberger D. R. (2017). Genetic insights into the neurodevelopmental origins of schizophrenia. Nat. Rev. Neurosci. 18, 727–740. 10.1038/nrn.2017.125 - DOI - PubMed

[10] Birnbaum R., Weinberger D. R. (2017). Genetic insights into the neurodevelopmental origins of schizophrenia. Nat. Rev. Neurosci. 18, 727–740. 10.1038/nrn.2017.125 - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment

Affiliations

Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources