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Review
. 2019 Feb;9(1):38-47.
doi: 10.15171/apb.2019.005. Epub 2019 Feb 21.

Signaling Pathways of Receptors Involved in Platelet Activation and Shedding of These Receptors in Stored Platelets

Asra Amelirad  1 , Karim Shamsasenjan  1 , Parvin Akbarzadehlaleh  2 , Davoud Pashoutan Sarvar  3
Affiliations
Review

Signaling Pathways of Receptors Involved in Platelet Activation and Shedding of These Receptors in Stored Platelets

Asra Amelirad et al. Adv Pharm Bull. 2019 Feb.

Abstract

All cells encounter various signals coming from the surrounding environment and they need to receive and respond to these signals in order to perform their functions. Cell surface receptors are responsible for signal transduction .Platelets are blood cells which perform several functions using diverse receptors. Platelet concentrate is one of the most consumed blood products. However, due to the short lifespan of the platelets and platelets damage during storage, we face shortage of platelet products. One of the damages that platelets undergo during storage is the loss of surface receptors. Since cell surface receptors are responsible for all cell functions, the loss of platelet receptors reduces the quality of platelet products. In this study, we reviewed the important receptors involved in platelet activation and their associated signaling pathways. We also looked at the platelet receptors that shed during storage and the causes of this incident. We found that GPIbα, P-selectin, CD40 and GPVI are platelet receptors that fall during platelet storage at room temperature. Considering that GPVI and GPIbα are the most important receptors which involved in platelet activation, their shedding can cause decrease in platelet activation after transfusion and decrease thrombus consistence. Shear stress and platelet contact with the container wall are among the mechanisms discussed in this process, but studies in this area have to be continued.

Keywords: ADAM Proteins; Metalloproteases; Platelet activation; Platelet membrane glycoproteinsins; Platelet storage pool deficiencycy; Platelet transfusion.

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