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Review
. 2020 May;95(5):485-492.
doi: 10.1111/cbdd.13529. Epub 2020 Feb 16.

Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization

Jiahao Zhang  1 , Shurong Wang  1 , Yuxi He  1 , Boyuan Yao  1 , Yan Zhang  1
Affiliations
Review

Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization

Jiahao Zhang et al. Chem Biol Drug Des. 2020 May.

Abstract

Corneal neovascularization (CNV), a pathological process of angiogenesis, can lead to serious consequences in the cornea. CNV is generally proved to associate with inflammation in the cornea closely, which is mainly elicited by the disruption of equilibrium between angiogenic and antiangiogenic factors. Angiogenic factors including vascular endothelial growth factors (VEGFs), basic fibroblast growth factors (bFGFs), and matrix metalloproteinases (MMPs) are vital factors in the formation of CNV. Especially VEGFs are convinced to be the core angiogenic factors in CNV, and MMPs are proved to exert dual effects on the process. Strikingly, matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) are determined to play key roles in the formation of CNV, while the mechanism is still vague. In this review, the latest researches are reviewed to discuss the role of MMP-2 and MMP-9 in CNV, respectively, and some inhibitors of them are presented. We hope to provide a new direction of drug research for CNV.

Keywords: corneal neovascularization; matrix metalloproteinase 2; matrix metalloproteinase 9; vascular endothelial growth factor.

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