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Review
. 2019 Mar 28:7:62.
doi: 10.3389/fbioe.2019.00062. eCollection 2019.

Using Bioactive Glasses in the Management of Burns

Saeid Kargozar  1 , Masoud Mozafari  2   3   4 , Sepideh Hamzehlou  5   6 , Francesco Baino  7
Affiliations
Review

Using Bioactive Glasses in the Management of Burns

Saeid Kargozar et al. Front Bioeng Biotechnol. .

Abstract

The management of burn injuries is considered an unmet clinical need and, to date, no fully satisfactory solution exists to this problem. This mini-review aims to explore the potential of bioactive glasses (BGs) for burn care due to the therapeutic effects of their ionic dissolution products. BGs have been studied for more than 40 years and boast a long successful history in the substitution of damaged tissues, especially bone. Considering their exceptional versatility and attractive characteristics, these synthetic materials have also recently been proposed in the treatment of soft tissue-related disorders such as skin wounds. Specifically, improving fibroblast proliferation, inducing angiogenesis, and eliciting antibacterial activity (with the additional advantage of avoiding administration of antibiotics) are all considered as key added values carried by BGs in the treatment of burn injuries. However, some issues deserve careful consideration while proceeding with the research, including the selection of suitable BG compositions, appropriate forms of application (e.g., BG fibers, ointments or composite patches), as well as the procedures for reliable in vivo testing.

Keywords: angiogenesis; antibacterial activity; bioactive glasses; burns; ion release; wound healing.

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Figures

Figure 1
Figure 1
The release of some metal ions from BGs into the surrounding environment has a positive effect on wound healing. Reproduced with some modifications from Naseri et al. (2017).
Figure 2
Figure 2
The biological effects of BGs are related to the release of therapeutic ions from their structure into the surrounding environment. Reproduced with some modifications from Kargozar et al. (2018a).
Figure 3
Figure 3
Direct observation of the burn wounds created in rats and treated with silk fibroin (SF)/chitosan (CHI), BG/SF, BG/CHI and BG/CHI/SF scaffolds after 3, 7, 14, 21, and 28 days. Reproduced with permission from Li et al. (2016a).
Figure 4
Figure 4
Schematic representation of possibilities of BGs for the treatment of burns. With some modifications from Homayoon (2015).
Figure 5
Figure 5
Cotton-like fibrous scaffolds produced and implanted subcutaneously in rats including (A) 45S5 glass, (B) 13–93B3 glass, and (C) Cu-doped 13–93B3 glass; (D) higher magnification of the 13–93B3 glass microfibers with glass beads of variable size; (E) the mat of copper-containing 13–93B3 glass microfibers for implantation in rats (E). Images reproduced from Lin et al. (2014) with permission.
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