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. 2019 Mar 12:10:230.
doi: 10.3389/fphys.2019.00230. eCollection 2019.

Effects of Mild Orthostatic Stimulation on Cerebral Pulsatile Hemodynamics

Yuka Ninomiya  1   2 , Tsubasa Tomoto  2   3   4 , Shigehiko Ogoh  5 , Tomoko Imai  6 , Koki Takahashi  1 , Jun Sugawara  2
Affiliations

Effects of Mild Orthostatic Stimulation on Cerebral Pulsatile Hemodynamics

Yuka Ninomiya et al. Front Physiol. .

Abstract

The augmented cerebral hemodynamic pulsatility could lead to the elevated risk of cerebrovascular disease. To determine the impact of an acute orthostatic challenge on a pulsatile component of cerebral hemodynamics, mild lower body negative pressure (LBNP, -30 mmHg) was applied to 29 men. Middle cerebral artery blood flow velocity (MCAv) was measured by transcranial Doppler technique. Stroke volume (SV) was estimated by the Modelflow method with adjustment by the Doppler ultrasound-measured SV at rest. SV, peak and pulsatile MCAv, and pulsatility index were significantly lower during the LBNP stimulation than those at the baseline (e.g., supine resting) (P < 0.05 for all), whereas mean arterial pressure and mean MCAv remained unchanged. The change in SV with the LBNP stimulation significantly correlated with corresponding changes in peak and pulsatile MCAv (r = 0.617, P < 0.001; r = 0.413, P = 0.026, respectively). These results suggest that pulsatile components of cerebrovascular hemodynamics are dampened during the transient period of orthostatic challenge (as simulated using LBNP) when compared to supine rest, and which is partly due to the modified SV.

Keywords: lower body negative pressure; orthostatic stress; pulsatility index; stroke volume; transcranial Doppler method.

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Figures

FIGURE 1
FIGURE 1
Responses of middle cerebral artery pulsatile hemodynamic measures to mild lower body negative pressure (LBNP) stimulation. Open circles and error bars are mean values and standard deviation. Thin lines indicate individual changes. MCAv = middle cerebral artery blood flow velocity.
See this image and copyright information in PMC

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