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Review
. 2020 Apr:220:88-96.
doi: 10.1016/j.imlet.2019.03.006. Epub 2019 Mar 15.

Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance

Yaqi Li  1 , Jing Liu  1 , Long Gao  1 , Yuan Liu  1 , Fang Meng  1 , Xiaoan Li  2 , F Xiao-Feng Qin  3
Affiliations
Review

Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance

Yaqi Li et al. Immunol Lett. 2020 Apr.

Abstract

The ability of immune checkpoint inhibitors (ICIs) to reactivate the killing function of the immune system to tumor cells has led to long lasting immune response presenting highly promising clinical advances. Recently, immune checkpoint inhibitors related resistance due to the specialized tumor microenvironment has also drawn a widely attention. To overcome resistance to immune checkpoint blockade therapy, understanding the relationship of this type of therapy and tumor microenvironment is necessary and critical. This review will focus on how the tumor environment influences the effectiveness of the immunotherapeutic check inhibitors. Finally, we provide a briefly succinct glimpse into the most exciting pre-clinical discoveries and ongoing clinical trials to overcome the resistance of ICIs.

Keywords: CTLA-4; Cancer immunotherapy; Immune checkpoint blockade resistance; PD-1/PD-L1; Tumor microenvironment.

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