Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections
- PMID: 30871179
- PMCID: PMC6466164
- DOI: 10.3390/v11030252
Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections
Abstract
Well-developed mouse models are important for understanding the pathogenesis and progression of immunological response to viral infections in humans. Moreover, to test vaccines, anti-viral drugs and therapeutic agents, mouse models are fundamental for preclinical investigations. Human viruses, however, seldom infect mice due to differences in the cellular receptors used by the viruses for entry, as well as in the innate immune responses in mice and humans. In other words, a species barrier exists when using mouse models for investigating human viral infections. Developing transgenic (Tg) mice models expressing the human genes coding for viral entry receptors and knock-out (KO) mice models devoid of components involved in the innate immune response have, to some extent, overcome this barrier. Humanized mouse models are a third approach, developed by engrafting functional human cells and tissues into immunodeficient mice. They are becoming indispensable for analyzing human viral diseases since they nearly recapitulate the human disease. These mouse models also serve to test the efficacy of vaccines and antiviral agents. This review provides an update on the Tg, KO, and humanized mouse models that are used in studies investigating the pathogenesis of three important human-specific viruses, namely human immunodeficiency (HIV) virus 1, influenza, and dengue.
Keywords: HIV; dengue; human viruses; humanized mice; infectious diseases; influenza; knockout mice; mouse models; transgenic mice.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Similar articles
-
Influenza and dengue virus co-infection impairs monocyte recruitment to the lung, increases dengue virus titers, and exacerbates pneumonia.Eur J Immunol. 2017 Mar;47(3):527-539. doi: 10.1002/eji.201646675. Epub 2017 Jan 12. Eur J Immunol. 2017. PMID: 27995614
-
The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017.Elife. 2024 May 28;12:RP90782. doi: 10.7554/eLife.90782. Elife. 2024. PMID: 38805550 Free PMC article.
-
Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing.J Virol. 2014 Feb;88(4):2205-18. doi: 10.1128/JVI.03085-13. Epub 2013 Dec 11. J Virol. 2014. PMID: 24335303 Free PMC article.
-
Humanized mouse models to study human cell-mediated and humoral responses to dengue virus.Curr Opin Virol. 2017 Aug;25:76-80. doi: 10.1016/j.coviro.2017.07.025. Epub 2017 Aug 9. Curr Opin Virol. 2017. PMID: 28802204 Free PMC article. Review.
-
Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview.Viruses. 2021 Aug 18;13(8):1641. doi: 10.3390/v13081641. Viruses. 2021. PMID: 34452505 Free PMC article. Review.
Cited by
-
DNA and protein-generated chimeric molecules for delivery of influenza viral epitopes in mouse and humanized NSG transfer models.Hum Vaccin Immunother. 2024 Dec 31;20(1):2292381. doi: 10.1080/21645515.2023.2292381. Epub 2024 Jan 9. Hum Vaccin Immunother. 2024. PMID: 38193304 Free PMC article. Review.
-
Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.Front Immunol. 2023 Mar 14;14:1076772. doi: 10.3389/fimmu.2023.1076772. eCollection 2023. Front Immunol. 2023. PMID: 36999019 Free PMC article.
-
Mice with humanized immune system as novel models to study HIV-associated pulmonary hypertension.Front Immunol. 2022 Aug 5;13:936164. doi: 10.3389/fimmu.2022.936164. eCollection 2022. Front Immunol. 2022. PMID: 35990658 Free PMC article.
-
Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection.Front Mol Neurosci. 2022 May 9;15:870868. doi: 10.3389/fnmol.2022.870868. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35615063 Free PMC article. Review.
-
Animal models for SARS-CoV-2 and SARS-CoV-1 pathogenesis, transmission and therapeutic evaluation.World J Virol. 2022 Jan 25;11(1):40-56. doi: 10.5501/wjv.v11.i1.40. World J Virol. 2022. PMID: 35117970 Free PMC article. Review.
References
-
- Global HIV and AIDS Statistics-2018 Fact Sheet. [(accessed on 28 August 2018)]; Available online: http://www.unaids.org/en/resources/fact-sheet.
-
- Nair H., Brooks W.A., Katz M., Roca A., Berkley J.A., Madhi S.A., Simmerman J.M., Gordon A., Sato M., Howie S., et al. Global burden of respiratory infections due to seasonal influenza in young children: A systematic review and meta-analysis. Lancet. 2011;378:1917–1930. doi: 10.1016/S0140-6736(11)61051-9. - DOI - PubMed
-
- Bot A., Casares S., Bot S., Von Boehmer H., Bona C. Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells. J. Immunol. 1998;160:4500–4507. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous