Neuroethics and the NIH BRAIN Initiative

doi:10.1080/23299460.2017.1319035

. 2018;5(1):122-130.

doi: 10.1080/23299460.2017.1319035. Epub 2017 May 5.

Neuroethics and the NIH BRAIN Initiative

Khara M Ramos¹, Karen S Rommelfanger², Henry T Greely³, Walter J Koroshetz⁴

Affiliations

¹ National Institute of Neurological Disorders and Stroke, 31 Center Dr, MSC 2540, Bethesda, MD 20892, 301-594-2614, khara.ramos@nih.gov.
² Emory University School of Medicine, Departments of Neurology and Psychiatry and Behavioral Sciences, Emory Center for Ethics Neuroethics Program, Atlanta, GA 30322, (404) 727-1150, krommel@emory.edu.
³ Stanford University, Stanford Law School, 559 Nathan Abbott Way, Stanford, CA 94305-8610, (650) 723-2517, hgreely@stanford.edu.
⁴ National Institute of Neurological Disorders and Stroke, 31 Center Dr, MSC 2540, Bethesda, MD 20892, 301-496-3167, koroshetzw@ninds.nih.gov.

PMID: 30854409
PMCID: PMC6405257
DOI: 10.1080/23299460.2017.1319035

Neuroethics and the NIH BRAIN Initiative

Khara M Ramos et al. J Responsible Innov. 2018.

. 2018;5(1):122-130.

doi: 10.1080/23299460.2017.1319035. Epub 2017 May 5.

Authors

Khara M Ramos¹, Karen S Rommelfanger², Henry T Greely³, Walter J Koroshetz⁴

Affiliations

¹ National Institute of Neurological Disorders and Stroke, 31 Center Dr, MSC 2540, Bethesda, MD 20892, 301-594-2614, khara.ramos@nih.gov.
² Emory University School of Medicine, Departments of Neurology and Psychiatry and Behavioral Sciences, Emory Center for Ethics Neuroethics Program, Atlanta, GA 30322, (404) 727-1150, krommel@emory.edu.
³ Stanford University, Stanford Law School, 559 Nathan Abbott Way, Stanford, CA 94305-8610, (650) 723-2517, hgreely@stanford.edu.
⁴ National Institute of Neurological Disorders and Stroke, 31 Center Dr, MSC 2540, Bethesda, MD 20892, 301-496-3167, koroshetzw@ninds.nih.gov.

PMID: 30854409
PMCID: PMC6405257
DOI: 10.1080/23299460.2017.1319035

Abstract

The Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is focused on developing new tools and neurotechnologies to revolutionize our understanding of how the brain functions in health and disease, in large part to address the growing societal impact of neurological, mental health, and substance abuse disorders. Recent advances in neurotechnology are delivering unprecedented ways to interrogate and modulate brain function, and the BRAIN Initiative is focused on translation for human medical uses over the next decade. Since its inception, the NIH component of the BRAIN Initiative has utilized an iterative model of integrating ethics into the scientific trajectory of the Initiative, most recently with the creation of a Neuroethics Division of the NIH BRAIN Initiative Multi-Council Working Group. The Division serves as a resource of expertise, to help the BRAIN Initiative navigate issues involving ethics. Here we discuss the BRAIN Initiative, and its implications and aspirations for neuroethics. We also discuss new opportunities for collaboration and for integrating stakeholder voices.

Keywords: BRAIN Initiative; neural circuits; neuroethics; neuromodulation; neuropsychiatric disorders.

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[1] Asai A, Kadooka Y, and Aizawa K 2012. “Arguments against promoting organ transplants from brain-dead donors, and views of contemporary Japanese on life and death.” Bioethics 26(4): 215–23. doi: 10.1111/j.1467-8519.2010.01839.x. - DOI - PubMed

[2] Asai A, Kadooka Y, and Aizawa K 2012. “Arguments against promoting organ transplants from brain-dead donors, and views of contemporary Japanese on life and death.” Bioethics 26(4): 215–23. doi: 10.1111/j.1467-8519.2010.01839.x. - DOI - PubMed

[3] Bell E, Leger P, Sankar T, and Racine E. 2016. “Deep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation.” Neurosurgery 79(1): pp. 3–10. doi: 10.1227/NEU.0000000000001207. - DOI - PubMed

[4] Bell E, Leger P, Sankar T, and Racine E. 2016. “Deep Brain Stimulation as Clinical Innovation: An Ethical and Organizational Framework to Sustain Deliberations About Psychiatric Deep Brain Stimulation.” Neurosurgery 79(1): pp. 3–10. doi: 10.1227/NEU.0000000000001207. - DOI - PubMed

[5] Bloom DE, Cafiero ET, Jané-Llopis E, Abrahams-Gessel S, Bloom LR, Fathima S, Feigl AB, Gaziano T, Mowafi M, Pandya A, Prettner K, Rosenberg L, Seligman B, Stein AZ, and Weinstein C. 2011. “The Global Economic Burden of Noncommunicable Diseases, World Economic Forum.” Available from: www.weforum.org/EconomicsOfNCD

[6] Bloom DE, Cafiero ET, Jané-Llopis E, Abrahams-Gessel S, Bloom LR, Fathima S, Feigl AB, Gaziano T, Mowafi M, Pandya A, Prettner K, Rosenberg L, Seligman B, Stein AZ, and Weinstein C. 2011. “The Global Economic Burden of Noncommunicable Diseases, World Economic Forum.” Available from: www.weforum.org/EconomicsOfNCD

[7] Brain Research through Advancing Innovative Neurotechnologies Initiative Working Group of the Advisory Committee to the NIH Director. 2014. “BRAIN 2025: A Scientific Vision.” Available from: https://www.braininitiative.nih.gov/2025/index.htm.

[8] Brain Research through Advancing Innovative Neurotechnologies Initiative Working Group of the Advisory Committee to the NIH Director. 2014. “BRAIN 2025: A Scientific Vision.” Available from: https://www.braininitiative.nih.gov/2025/index.htm.

[9] Brose K 2016. “Global Neuroscience.” Neuron 92(3): pp. 557–558. doi: 10.1016/j.neuron.2016.10.047. - DOI - PubMed

[10] Brose K 2016. “Global Neuroscience.” Neuron 92(3): pp. 557–558. doi: 10.1016/j.neuron.2016.10.047. - DOI - PubMed

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Neuroethics and the NIH BRAIN Initiative

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Neuroethics and the NIH BRAIN Initiative

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Abstract

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