Comparative Study
doi: 10.1073/pnas.83.5.1251.
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase
- PMID: 3081893
- PMCID: PMC323053
- DOI: 10.1073/pnas.83.5.1251
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Comparative Study
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase
Proc Natl Acad Sci U S A.
1986 Mar.
Abstract
A bovine adrenal cDNA clone encoding the entire alpha subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (Gs) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of Gs alpha with the alpha subunit of another G protein, transducin, revealed striking homologies.
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