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. 2019 Feb 11;8(2):e1043.
doi: 10.1002/cti2.1043. eCollection 2019.

A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population

Silvia Lee  1   2 , Emily Brook  1 , Jacquita Affandi  3 , Prue Howson  4 , Selita Agnes Tanudjaja  3 , Satvinder Dhaliwal  3 , Ashley Irish  4 , Patricia Price  1
Affiliations

A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population

Silvia Lee et al. Clin Transl Immunology. .

Abstract

Objectives: Meta-analyses have now confirmed that persistent infections with cytomegalovirus (CMV) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the viral burden.

Results: We compare markers of the burden of CMV with established indices of vascular pathology in healthy adults (n = 82) and in renal transplant recipients (RTR; n = 81). Levels of all inflammatory and vascular biomarkers and CMV antibodies were higher in RTR, and flow-mediated dilation (FMD) values were lower indicating inferior endothelial function. In multivariable regression models without adjustment for estimated glomerular filtration rate (eGFR), CMV antibody levels, age and gender were independently associated with FMD in RTR, whilst only CRP associated with FMD in healthy adults. After adjustment for eGFR, associations between CMV antibody and FMD in RTR were reduced.

Methods: Carotid intima-media thickness, FMD, eGFR and plasma levels of CMV antibodies (reactive with a lysate, CMV IE-1 or CMV gB), ICAM-1, VCAM-1, P-selectin, sIFNαR2, sTNFR1, sCD14 and CRP were determined.

Conclusion: Levels of CMV antibody predict declining endothelial health in RTR and not in healthy adults, presumably by reflecting a high burden of CMV. The levels of CMV antibodies were a poor reflection of plasma biomarkers thought to reflect 'inflammaging' or vascular damage.

Keywords: cytomegalovirus; inflammatory biomarkers; transplantation; vascular pathology.

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References

    1. Sinzger C, Digel M, Jahn G. Cytomegalovirus cell tropism. Curr Top Microbiol Immunol 2008; 325: 63–83. - PubMed
    1. Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 2010; 20: 202–213. - PubMed
    1. Prosch S, Wendt C, Reinke P et al A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation. Virology 2000; 27: 357–365. - PubMed
    1. Griffiths PD. Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation. Lancet Infect Dis 2012; 12: 790–798. - PubMed
    1. Trzonkowski P, Mysliwska J, Szmit E et al Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti‐hemagglutinins during the anti‐influenza vaccination ‐ an impact of immunosenescence. Vaccine 2003; 21: 3826–3836. - PubMed

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