Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

doi:10.3389/fimmu.2019.00135

Review

. 2019 Feb 1:10:135.

doi: 10.3389/fimmu.2019.00135. eCollection 2019.

Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

Aloysious Ssemaganda¹, Ashwini Kumar Giddam¹, Mehfuz Zaman¹, Mariusz Skwarczynski², Istvan Toth^{2

3

4}, Danielle I Stanisic¹, Michael F Good¹

Affiliations

¹ Institute for Glycomics, Griffith University, Southport, QLD, Australia.
² School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
³ School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.
⁴ Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

PMID: 30774635
PMCID: PMC6367261
DOI: 10.3389/fimmu.2019.00135

Review

Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

Aloysious Ssemaganda et al. Front Immunol. 2019.

. 2019 Feb 1:10:135.

doi: 10.3389/fimmu.2019.00135. eCollection 2019.

Authors

Aloysious Ssemaganda¹, Ashwini Kumar Giddam¹, Mehfuz Zaman¹, Mariusz Skwarczynski², Istvan Toth^{2

3

4}, Danielle I Stanisic¹, Michael F Good¹

Affiliations

¹ Institute for Glycomics, Griffith University, Southport, QLD, Australia.
² School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
³ School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.
⁴ Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

PMID: 30774635
PMCID: PMC6367261
DOI: 10.3389/fimmu.2019.00135

Abstract

In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against Plasmodium parasites, liposome design considerations and their current application in the development of a malaria vaccine.

Trial registration: ClinicalTrials.gov NCT02905019.

Keywords: Plasmodium; adjuvant; immunity; liposomes; malaria; vaccine.

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Figures

**Figure 1**
Major liposome physicochemical characteristics that can be modified to direct immune responses elicited following vaccination (9).

See this image and copyright information in PMC

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References

1. Russell PF, Mohan BN. The immunisation of fowls against mosquito-borne Plasmodium Gallinaceum by injections of serum and of inactivated homologous sporozoites. J Exp Med. (1942) 76:477–95. 10.1084/jem.76.5.477 - DOI - PMC - PubMed
1. Hill AV. Vaccines against malaria. Philos Trans R Soc Lond B Biol Sci. (2011) 366:2806–14. 10.1098/rstb.2011.0091 - DOI - PMC - PubMed
1. Freund J, Sommer HE, Walter AW. Immunisation against malaria: vaccination of ducks with killed parasites incorporated with adjuvants. Science (1945) 102:200–2. 10.1126/science.102.2643.200 - DOI - PubMed
1. Freund J, Thomson KJ, Sommer HE, Walter AW, Schenkein EL. Immunisation of rhesus monkeys against malarial infection (P. knowlesi) with killed parasites and adjuvants. Science (1945) 102:202–4. 10.1126/science.102.2643.202 - DOI - PubMed
1. Nussenzweig RS, Vanderberg J, Most H, Orton C. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. Nature (1967) 216:160–2. 10.1038/216160a0 - DOI - PubMed

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[1] Russell PF, Mohan BN. The immunisation of fowls against mosquito-borne Plasmodium Gallinaceum by injections of serum and of inactivated homologous sporozoites. J Exp Med. (1942) 76:477–95. 10.1084/jem.76.5.477 - DOI - PMC - PubMed

[2] Russell PF, Mohan BN. The immunisation of fowls against mosquito-borne Plasmodium Gallinaceum by injections of serum and of inactivated homologous sporozoites. J Exp Med. (1942) 76:477–95. 10.1084/jem.76.5.477 - DOI - PMC - PubMed

[3] Hill AV. Vaccines against malaria. Philos Trans R Soc Lond B Biol Sci. (2011) 366:2806–14. 10.1098/rstb.2011.0091 - DOI - PMC - PubMed

[4] Hill AV. Vaccines against malaria. Philos Trans R Soc Lond B Biol Sci. (2011) 366:2806–14. 10.1098/rstb.2011.0091 - DOI - PMC - PubMed

[5] Freund J, Sommer HE, Walter AW. Immunisation against malaria: vaccination of ducks with killed parasites incorporated with adjuvants. Science (1945) 102:200–2. 10.1126/science.102.2643.200 - DOI - PubMed

[6] Freund J, Sommer HE, Walter AW. Immunisation against malaria: vaccination of ducks with killed parasites incorporated with adjuvants. Science (1945) 102:200–2. 10.1126/science.102.2643.200 - DOI - PubMed

[7] Freund J, Thomson KJ, Sommer HE, Walter AW, Schenkein EL. Immunisation of rhesus monkeys against malarial infection (P. knowlesi) with killed parasites and adjuvants. Science (1945) 102:202–4. 10.1126/science.102.2643.202 - DOI - PubMed

[8] Freund J, Thomson KJ, Sommer HE, Walter AW, Schenkein EL. Immunisation of rhesus monkeys against malarial infection (P. knowlesi) with killed parasites and adjuvants. Science (1945) 102:202–4. 10.1126/science.102.2643.202 - DOI - PubMed

[9] Nussenzweig RS, Vanderberg J, Most H, Orton C. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. Nature (1967) 216:160–2. 10.1038/216160a0 - DOI - PubMed

[10] Nussenzweig RS, Vanderberg J, Most H, Orton C. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. Nature (1967) 216:160–2. 10.1038/216160a0 - DOI - PubMed

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Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

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Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

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