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Review
. 2019 May:122:52-75.
doi: 10.1016/j.bone.2019.02.013. Epub 2019 Feb 14.

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

Affiliations
Review

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

D Bellavia et al. Bone. 2019 May.

Abstract

MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.

Keywords: Osteoblast; Osteoclast; Osteogenesis; Osteoporosis; miRNA.

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