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Review
. 2019 Jan 29:10:92.
doi: 10.3389/fimmu.2019.00092. eCollection 2019.

Type 3 ILCs in Lung Disease

Amanda Ardain  1   2 , James Zachary Porterfield  1   2   3 , Henrik N Kløverpris  1   4   5 , Alasdair Leslie  1   5
Affiliations
Review

Type 3 ILCs in Lung Disease

Amanda Ardain et al. Front Immunol. .

Abstract

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.

Keywords: COPD; ILC3; airway hypersensitivity; lung disease; pnemonia; pulmonary fibrosis; tuberulosis.

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Figures

Figure 1
Figure 1
Under conditions of stress or infection, ILC3s produce an array of effector cytokines in response to activating ligands secreted by phagocytic mononuclear cells.
Figure 2
Figure 2
Diverse and overlapping roles of IL-22 and IL-17 within the lung.
See this image and copyright information in PMC

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