The value of MYB as a prognostic marker for adenoid cystic carcinoma: Meta-analysis
- PMID: 30759319
- DOI: 10.1002/hed.25597
The value of MYB as a prognostic marker for adenoid cystic carcinoma: Meta-analysis
Abstract
The aim of this meta-analysis is to evaluate myeloblastosis (MYB) as a prognostic marker for patients with adenoid cystic carcinoma (ACC) with respect to MYB gene fusion, MYB protein expression, and tumor sites. We comprehensively searched PubMed, Embase, Web of Science, and Cochrane libraries. Ten studies concerning the prognostic comparisons between MYB positivity and negativity were included. The combined positive rates of MYB gene fusion and protein expression were 57.2% and 62.3%, respectively. Overall, no significant prognostic differences were observed between MYB-positive and MYB-negative ACCs. When further divided into MYB gene fusion and MYB protein expression subgroups, no significant differences were observed for any survival outcome (overall survival, disease-free survival, and local control rate). Moreover, MYB also demonstrated no prognostic value in head and neck ACCs. In conclusion, the current studies reveal that MYB is not a good prognostic marker for ACC.
Keywords: MYB; adenoid cystic carcinoma; gene fusion; meta-analysis; prognosis.
© 2019 Wiley Periodicals, Inc.
Similar articles
-
MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma.Laryngoscope. 2015 Sep;125(9):E292-9. doi: 10.1002/lary.25356. Epub 2015 May 11. Laryngoscope. 2015. PMID: 25963073 Free PMC article.
-
Detection of MYB Alterations and Other Immunohistochemical Markers in Primary Cutaneous Adenoid Cystic Carcinoma.Am J Surg Pathol. 2015 Oct;39(10):1347-56. doi: 10.1097/PAS.0000000000000463. Am J Surg Pathol. 2015. PMID: 26076064
-
The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Sep;160(3):417-22. doi: 10.5507/bp.2016.027. Epub 2016 May 12. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016. PMID: 27174194
-
Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials.Head Neck. 2016 Apr;38(4):620-7. doi: 10.1002/hed.23925. Epub 2015 Jun 16. Head Neck. 2016. PMID: 25487882 Free PMC article. Review.
-
Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis.Oncotarget. 2017 Apr 25;8(17):29458-29473. doi: 10.18632/oncotarget.15297. Oncotarget. 2017. PMID: 28206977 Free PMC article. Review.
Cited by
-
Rearrangements, Expression, and Clinical Significance of MYB and MYBL1 in Adenoid Cystic Carcinoma: A Multi-Institutional Study.Cancers (Basel). 2022 Jul 28;14(15):3691. doi: 10.3390/cancers14153691. Cancers (Basel). 2022. PMID: 35954356 Free PMC article.
-
Recent Advances, Systemic Therapy, and Molecular Targets in Adenoid Cystic Carcinoma of the Head and Neck.J Clin Med. 2023 Feb 12;12(4):1463. doi: 10.3390/jcm12041463. J Clin Med. 2023. PMID: 36835997 Free PMC article. Review.
-
Approaches to the Management of Metastatic Adenoid Cystic Carcinoma.Cancers (Basel). 2022 Nov 20;14(22):5698. doi: 10.3390/cancers14225698. Cancers (Basel). 2022. PMID: 36428790 Free PMC article. Review.
-
Cavernous sinus adenoid cystic carcinoma mimicking meningioma: a case study and literature analysis.Quant Imaging Med Surg. 2024 Jan 3;14(1):1288-1296. doi: 10.21037/qims-23-938. Epub 2023 Dec 12. Quant Imaging Med Surg. 2024. PMID: 38223082 Free PMC article. No abstract available.
-
Outcome-oriented clinicopathological reappraisal of sinonasal adenoid cystic carcinoma with broad morphological spectrum and high MYB::NFIB prevalence.Sci Rep. 2024 Aug 12;14(1):18655. doi: 10.1038/s41598-024-69039-6. Sci Rep. 2024. PMID: 39134604 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
