Hypoxic Tumors Share Genomic Instability
- PMID: 30723077
- DOI: 10.1158/2159-8290.CD-NB2019-012
Hypoxic Tumors Share Genomic Instability
Abstract
A genomic analysis of 8,006 tumors spanning 19 cancer types suggests that hypoxic tumors share common features, including genomic instability. Eleven types of cancer carried extra copies of MYC, and seven types had lost PTEN. The study also found that miRNA dysregulation was prevalent across tumor types.
©2019 American Association for Cancer Research.
Comment on
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Molecular landmarks of tumor hypoxia across cancer types.Nat Genet. 2019 Feb;51(2):308-318. doi: 10.1038/s41588-018-0318-2. Epub 2019 Jan 14. Nat Genet. 2019. PMID: 30643250
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