Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb 4;24(1):8.
doi: 10.1186/s40001-019-0363-z.

Neuroendocrine carcinoma of gallbladder: a case series and literature review

Wei Liu  1 , Weijie Chen  1 , Jiemin Chen  1 , Tao Hong  1 , Binglu Li  1 , Qiang Qu  1 , Xiaodong He  2
Affiliations
Review

Neuroendocrine carcinoma of gallbladder: a case series and literature review

Wei Liu et al. Eur J Med Res. .

Abstract

Background: Neuroendocrine carcinoma (NEC) of gallbladder is a rare tumor. The clinical manifestation, treatment, and prognosis of gallbladder NEC are rarely reported.

Case presentation: Eight gallbladder NEC patients were admitted into our hospital. The major complaint was right upper quadrant pain. Two patients underwent a radical resection of gallbladder and liver quadrate lobe. One of them underwent chemotherapies and had no recurrence of NEC during a 25-month followed-up period. The other patient did not undergo chemotherapies, and the NEC recurred in the patient 15 months afterwards. Two patients underwent a radical resection of gallbladder. One of them underwent chemotherapies and had an NEC recurrence 12 months afterwards. The other patient did not undergo chemotherapies and died due to the NEC recurrence 5 months after surgery. Three patients underwent a laparoscopic cholecystectomy and pathologic result showed gallbladder NEC. They did not undergo further treatment and no NEC recurrence was found. One patient underwent tumor biopsy and died due to obstructive jaundice 3 months afterwards. Pathologic results showed that all cases had positive chromogranin A and synaptophysin staining.

Conclusions: Gallbladder NEC showed no noticeably specific features, and the diagnosis relied on the pathological and immunohistochemistrical results. For T1N0M0 gallbladder NEC, cholecystectomy might be enough. For patients in a late stage, the management of combined therapies might be optimal.

Keywords: Gallbladder; Neuroendocrine carcinoma; Neuroendocrine tumor; Surgery.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
MRI and immunohistochemistry of gallbladder neuroendocrine carcinoma. a, b MRI image of gallbladder. The arrow showing a mass in the gallbladder. c HE staining of carcinoma tissues form gallbladder (×200). d CgA staining shows CgA positive cancer cells (×200)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ayub F, Saif MW. Neuroendocrine tumor of the cystic duct: a rare and incidental diagnosis. Cureus. 2017;9:e1755. - PMC - PubMed
    1. Chen C, Wang L, Liu X, Zhang G, Zhao Y, Geng Z. Gallbladder neuroendocrine carcinoma: report of 10 cases and comparision of clinicopathologic features with gallbladder adenocarcinoma. Int J Clin Exp Pathol. 2015;8:8218–8226. - PMC - PubMed
    1. Capella C, Heitz PU, Hofler H, Solcia E, Kloppel G. Revised classification of neuroendocrine tumours of the lung, pancreas and gut. Virchows Arch. 1995;425:547–560. doi: 10.1007/BF00199342. - DOI - PubMed
    1. Sakamoto H, Mutoh H, Ido K, Satoh K, Hayakawa H, Sugano K. A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis. Hum Pathol. 2007;38:66–71. doi: 10.1016/j.humpath.2006.06.010. - DOI - PubMed
    1. Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y, D’Angelica M, Dematteo RP, Blumgart LH, O’Reilly EM. Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC) J Surg Oncol. 2008;98:485–489. doi: 10.1002/jso.21141. - DOI - PubMed

Substances