The effects of ATP on the contractions of rat and mouse fast skeletal muscle
- PMID: 30677146
- DOI: 10.1002/mus.26423
The effects of ATP on the contractions of rat and mouse fast skeletal muscle
Abstract
Introduction: The aim of this study was to compare the effects of adenosine-5'-triphosphate (ATP) and adenosine on the contractility of rodent extensor digitorum longus (EDL) muscle at normal and low temperatures.
Methods: Contractions of rat and mouse isolated EDL were induced by either electrical stimulation (ES) or exogenous carbachol and recorded in the presence of ATP or adenosine (both at 100 μM).
Results: ATP at all temperatures caused a decrease of the contractions induced by carbachol in rat and mouse EDL and ES-induced contractions in rat EDL, while it potentiated the ES-induced contractions of mouse EDL. Adenosine reduced the contractility of rat and mouse EDL evoked by ES and did not affect the carbachol-induced contractions of rat and mouse EDL at any temperature.
Discussion: Under various temperature conditions, ATP inhibits pre- but potentiates postsynaptic processes in the mouse EDL; in the rat EDL ATP causes only inhibition of neuromuscular conduction. Muscle Nerve 59:509-516, 2019.
Keywords: ATP; P2 receptors; adenosine; extensor digitorum longus; fast skeletal muscle; hypothermia.
© 2019 Wiley Periodicals, Inc.
Similar articles
-
Effects of ATP and adenosine on contraction amplitude of rat soleus muscle at different temperatures.Muscle Nerve. 2017 Mar;55(3):417-423. doi: 10.1002/mus.25263. Epub 2016 Oct 1. Muscle Nerve. 2017. PMID: 27448234
-
The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle.Eur J Pharmacol. 2005 Feb 21;509(2-3):187-93. doi: 10.1016/j.ejphar.2004.11.031. Eur J Pharmacol. 2005. PMID: 15733555
-
Stimulation pulse characteristics and electrode configuration determine site of excitation in isolated mammalian skeletal muscle: implications for fatigue.J Appl Physiol (1985). 2007 Jul;103(1):359-68. doi: 10.1152/japplphysiol.01267.2006. Epub 2007 Apr 5. J Appl Physiol (1985). 2007. PMID: 17412789
-
The myoneural effects of lithium chloride on the nerve-muscle preparations of rats. Role of adenosine triphosphate-sensitive potassium channels.Pharmacol Res. 2000 Feb;41(2):163-78. doi: 10.1006/phrs.1999.0574. Pharmacol Res. 2000. PMID: 10623484
-
Different effects of ATP on the contractile activity of mice diaphragmatic and skeletal muscles.Neurochem Int. 2006 Dec;49(8):756-63. doi: 10.1016/j.neuint.2006.06.007. Epub 2006 Aug 9. Neurochem Int. 2006. PMID: 16904240
Cited by
-
Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission.Curr Issues Mol Biol. 2023 Oct 19;45(10):8492-8501. doi: 10.3390/cimb45100535. Curr Issues Mol Biol. 2023. PMID: 37886978 Free PMC article.
-
Purinergic Tuning of the Tripartite Neuromuscular Synapse.Mol Neurobiol. 2023 Jul;60(7):4084-4104. doi: 10.1007/s12035-023-03317-8. Epub 2023 Apr 5. Mol Neurobiol. 2023. PMID: 37016047 Free PMC article. Review.
-
P2 Receptor Signaling in Motor Units in Muscular Dystrophy.Int J Mol Sci. 2023 Jan 13;24(2):1587. doi: 10.3390/ijms24021587. Int J Mol Sci. 2023. PMID: 36675094 Free PMC article. Review.
-
Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission.Int J Mol Sci. 2020 Sep 3;21(17):6423. doi: 10.3390/ijms21176423. Int J Mol Sci. 2020. PMID: 32899290 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
