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. 1988 Nov;8(6):447-52.
doi: 10.1007/BF00916949.

Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

G Semenzato  1 , L M Bambara, D Biasi, A Frigo, F Vinante, B Zuppini, L Trentin, C Feruglio, M Chilosi, G Pizzolo
Affiliations

Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

G Semenzato et al. J Clin Immunol. 1988 Nov.

Abstract

In this study we investigated the serum levels of a released soluble form of the interleukin-2 receptor (sIL-2R) in 42 patients with rheumatoid arthritis and in 12 cases of systemic lupus erythematosus. Data were evaluated in relationship to the clinical phase and compared with those observed in normal controls (N = 56) and in osteoarthritis (N = 7). Increased levels were observed in both rheumatoid arthritis (mean +/- SE, 604 +/- 49 U/ml) and systemic lupus erythematosus (1438 +/- 481 U/ml). These values were significantly higher than in control (256 +/- 15 U/ml; P less than 0.001) and in osteoarthritis (298 +/- 33 U/ml; P less than 0.001) groups. In addition, the highest values were associated with the active phases of both rheumatoid arthritis (active vs inactive, 771 +/- 78 vs 451 +/- 39 U/ml; P less than 0.001) and systemic lupus erythematosus (active vs inactive, 2108 +/- 489 vs 499 +/- 75 U/ml; P less than 0.001). Our findings suggest that the detection of sIL-2R in rheumatoid arthritis and in systemic lupus erythematosus may represent a good marker of disease activity, which indirectly indicates the ongoing activation and/or proliferation of immunoreactive cells which are involved in the pathogenetic events of these autoimmune conditions.

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References

    1. Sarcoidosis. 1987 Sep;4(2):87-93 - PubMed
    1. Arthritis Rheum. 1987 Jul;30(7):737-43 - PubMed
    1. N Engl J Med. 1984 Oct 18;311(16):1019-29 - PubMed
    1. Clin Immunol Immunopathol. 1987 Nov;45(2):252-8 - PubMed
    1. Clin Immunol Immunopathol. 1987 May;43(2):273-6 - PubMed

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