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. 2019 Jan;27(1):111-117.
doi: 10.1016/j.jfda.2018.05.007. Epub 2018 Jun 18.

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei-Chuan Chen  1   2 , Guei-Jane Wang  3   4   5 , Yueh-Hsiung Kuo  6   7 , Yin-Ru Chiang  8 , Ting-Yu Cho  1 , Yu-Ming Ju  9 , Tzong-Huei Lee  10
Affiliations

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei-Chuan Chen et al. J Food Drug Anal. 2019 Jan.

Abstract

Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

Keywords: Anti-inflammation; Fimbriether; Isoprenyl phenolic ether; Nitric oxide inhibition; Xylaria fimbriata.

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Conflict of interest statement

Conflicts of interest

The authors declare that there are no potential conflicts of interest.

Figures

Fig. 1
Fig. 1
Chemical structures of compounds 1–7 identified in this report.
Fig. 2
Fig. 2
Key COSY and HMBC correlations of 1.
Fig. 3
Fig. 3
Key COSY and HMBC correlations of 6 and 7.
Fig. 4
Fig. 4
13C NMR data of the C-1′–C-5′ moiety of 6, 7, and literature data.
See this image and copyright information in PMC

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References

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Grants and funding

This work was supported by grant-in-aid from the Taiwan Ministry of Science and Technology (MOST104-2320-B-002-007-MY3) for THLee, the China Medical University Hospital Foundation (DMR-105-091) for GJWang, the China Medical University under the Aim for Top University of the Ministry of Education, Taiwan (CHM106-5-2), and Taiwan Ministry of Health and Welfare Clinical Trial Center, Taiwan (MOHW 106- TDU-B-212-113004) for YHKuo.

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