Impact of infection on risk of Parkinson's disease: a quantitative assessment of case-control and cohort studies

doi:10.1007/s13365-018-0707-4

Meta-Analysis

. 2019 Apr;25(2):221-228.

doi: 10.1007/s13365-018-0707-4. Epub 2019 Jan 10.

Impact of infection on risk of Parkinson's disease: a quantitative assessment of case-control and cohort studies

Lei Meng^{1

2}, Liang Shen^{3

4}, Hong-Fang Ji^{5

6}

Affiliations

¹ Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
² Zibo Key Laboratory for Neurodegenerative Diseases Drug Development, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
³ Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China. shen@sdut.edu.cn.
⁴ Zibo Key Laboratory for Neurodegenerative Diseases Drug Development, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China. shen@sdut.edu.cn.
⁵ Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China. jhf@sdut.edu.cn.
⁶ Zibo Key Laboratory for Neurodegenerative Diseases Drug Development, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China. jhf@sdut.edu.cn.

PMID: 30632012
DOI: 10.1007/s13365-018-0707-4

Meta-Analysis

Impact of infection on risk of Parkinson's disease: a quantitative assessment of case-control and cohort studies

Lei Meng et al. J Neurovirol. 2019 Apr.

. 2019 Apr;25(2):221-228.

doi: 10.1007/s13365-018-0707-4. Epub 2019 Jan 10.

Authors

Lei Meng^{1

2}, Liang Shen^{3

4}, Hong-Fang Ji^{5

6}

Affiliations

¹ Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
² Zibo Key Laboratory for Neurodegenerative Diseases Drug Development, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
³ Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China. shen@sdut.edu.cn.
⁴ Zibo Key Laboratory for Neurodegenerative Diseases Drug Development, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China. shen@sdut.edu.cn.
⁵ Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China. jhf@sdut.edu.cn.
⁶ Zibo Key Laboratory for Neurodegenerative Diseases Drug Development, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China. jhf@sdut.edu.cn.

PMID: 30632012
DOI: 10.1007/s13365-018-0707-4

Abstract

Identifying modifiable risk factors for Parkinson's disease (PD) to help prevent this disease has attracted increasing interest in recent years for the limited effective drugs at present. Despite many studies indicated that infection acts as a risk factor for PD, there is no quantitative assessment of the impact of viral and bacterial infections on the risk of developing PD. The present study performed a meta-analysis on the basis of 38 datasets from 13 studies covering 287,773 PD cases and 7,102,901 controls to ascertain the association between PD and infection and the differences in the strength of the viral and bacterial infections. The overall meta-analytic results indicated that individuals with infection had a 20% increased risk of PD compared with controls (OR 1.20, 95%CI 1.07-1.32). The subgroup analysis according to the type of infection found that bacterial infection had a significant impact on increased risk of PD (OR 1.40, 95%CI 1.32-1.48). The present analysis indicated that infection could increase the risk of developing PD, and physician should be aware of the risk of developing PD in subjects with infection.

Keywords: Bacteria; Infection; Meta-analysis; Parkinson’s disease; Virus.

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[1] JAMA. 2000 May 24-31;283(20):2674-9 - PubMed

[2] JAMA. 2000 May 24-31;283(20):2674-9 - PubMed

[3] J Neuropsychiatry Clin Neurosci. 2002 Spring;14(2):223-36; discussion 222 - PubMed

[4] J Neuropsychiatry Clin Neurosci. 2002 Spring;14(2):223-36; discussion 222 - PubMed

[5] Environ Health Perspect. 2003 Jun;111(8):1065-73 - PubMed

[6] Environ Health Perspect. 2003 Jun;111(8):1065-73 - PubMed

[7] Eur J Neurosci. 2004 Jan;19(1):85-92 - PubMed

[8] Eur J Neurosci. 2004 Jan;19(1):85-92 - PubMed

[9] Nat Rev Drug Discov. 2004 Mar;3(3):205-14 - PubMed

[10] Nat Rev Drug Discov. 2004 Mar;3(3):205-14 - PubMed

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Impact of infection on risk of Parkinson's disease: a quantitative assessment of case-control and cohort studies

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Impact of infection on risk of Parkinson's disease: a quantitative assessment of case-control and cohort studies

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