The dynamic nature of senescence in cancer

doi:10.1038/s41556-018-0249-2

Review

. 2019 Jan;21(1):94-101.

doi: 10.1038/s41556-018-0249-2. Epub 2019 Jan 2.

The dynamic nature of senescence in cancer

Soyoung Lee^{1

2

3}, Clemens A Schmitt^{4

5

6}

Affiliations

¹ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Berlin, Germany.
² Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
³ Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin, Berlin, Germany.
⁴ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Berlin, Germany. clemens.schmitt@charite.de.
⁵ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. clemens.schmitt@charite.de.
⁶ Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin, Berlin, Germany. clemens.schmitt@charite.de.

PMID: 30602768
DOI: 10.1038/s41556-018-0249-2

Review

The dynamic nature of senescence in cancer

Soyoung Lee et al. Nat Cell Biol. 2019 Jan.

. 2019 Jan;21(1):94-101.

doi: 10.1038/s41556-018-0249-2. Epub 2019 Jan 2.

Authors

Soyoung Lee^{1

2

3}, Clemens A Schmitt^{4

5

6}

Affiliations

¹ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Berlin, Germany.
² Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
³ Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin, Berlin, Germany.
⁴ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Berlin, Germany. clemens.schmitt@charite.de.
⁵ Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. clemens.schmitt@charite.de.
⁶ Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin, Berlin, Germany. clemens.schmitt@charite.de.

PMID: 30602768
DOI: 10.1038/s41556-018-0249-2

Abstract

Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy, and characterize these properties, such as reprogramming into stemness, tissue remodelling and immune crosstalk, as far more dynamic than suggested by the common view of senescence as an irreversible, static condition.

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References

1. Hayflick, L. & Moorhead, P. S. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961). - PubMed - DOI
1. Childs, B. G., Durik, M., Baker, D. J. & van Deursen, J. M. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat. Med. 21, 1424–1435 (2015). - PubMed - PMC - DOI
1. Shay, J. W. Role of telomeres and telomerase in aging and cancer. Cancer Discov. 6, 584–593 (2016). - PubMed - PMC - DOI
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[1] Hayflick, L. & Moorhead, P. S. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961). - PubMed - DOI

[2] Hayflick, L. & Moorhead, P. S. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961). - PubMed - DOI

[3] Childs, B. G., Durik, M., Baker, D. J. & van Deursen, J. M. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat. Med. 21, 1424–1435 (2015). - PubMed - PMC - DOI

[4] Childs, B. G., Durik, M., Baker, D. J. & van Deursen, J. M. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat. Med. 21, 1424–1435 (2015). - PubMed - PMC - DOI

[5] Shay, J. W. Role of telomeres and telomerase in aging and cancer. Cancer Discov. 6, 584–593 (2016). - PubMed - PMC - DOI

[6] Shay, J. W. Role of telomeres and telomerase in aging and cancer. Cancer Discov. 6, 584–593 (2016). - PubMed - PMC - DOI

[7] Kuilman, T., Michaloglou, C., Mooi, W. J. & Peeper, D. S. The essence of senescence. Genes Dev. 24, 2463–2479 (2010). - PubMed - PMC - DOI

[8] Kuilman, T., Michaloglou, C., Mooi, W. J. & Peeper, D. S. The essence of senescence. Genes Dev. 24, 2463–2479 (2010). - PubMed - PMC - DOI

[9] Kuilman, T. & Peeper, D. S. Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer 9, 81–94 (2009). - PubMed - DOI

[10] Kuilman, T. & Peeper, D. S. Senescence-messaging secretome: SMS-ing cellular stress. Nat. Rev. Cancer 9, 81–94 (2009). - PubMed - DOI

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The dynamic nature of senescence in cancer

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The dynamic nature of senescence in cancer

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