Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic

doi:10.1016/j.jconrel.2018.12.019

Review

. 2019 Jan 28:294:102-113.

doi: 10.1016/j.jconrel.2018.12.019. Epub 2018 Dec 13.

Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic

Hong-Hui Wu¹, Yi Zhou¹, Yasuhiko Tabata², Jian-Qing Gao³

Affiliations

¹ Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, PR China.
² Laboratory of Biomaterials, Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
³ Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, PR China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China. Electronic address: gaojianqing@zju.edu.cn.

PMID: 30553849
DOI: 10.1016/j.jconrel.2018.12.019

Review

Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic

Hong-Hui Wu et al. J Control Release. 2019.

. 2019 Jan 28:294:102-113.

doi: 10.1016/j.jconrel.2018.12.019. Epub 2018 Dec 13.

Authors

Hong-Hui Wu¹, Yi Zhou¹, Yasuhiko Tabata², Jian-Qing Gao³

Affiliations

¹ Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, PR China.
² Laboratory of Biomaterials, Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
³ Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, PR China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China. Electronic address: gaojianqing@zju.edu.cn.

PMID: 30553849
DOI: 10.1016/j.jconrel.2018.12.019

Abstract

Owing to the diversity and ease of preparation of nanomaterials, the rational nanocarriers with a rational design have become increasingly popular in medical researches. Although nanoparticle-based drug delivery exhibits great potential, there are some challenges facing like rapid plasma clearance, triggering or aggravation of immune response, etc. Herein, cell-based targeted drug delivery systems have drawn more and more attention owing to low immunogenicity and intrinsic mutation rate, and innate ability to allow targeted delivery. Mesenchymal stem cells (MSCs) have been used in gene and drug delivery. The use of MSCs is a promising approach for the development of gene transfer systems and drug loading strategies because of their intrinsic properties, including homing ability and tumor tropism. By combining the inherent cell properties and merits of synthetic nanoparticles (NPs), cell membrane coated NPs emerge as the time requires. Overall, we provide a comprehensive overview of the utility of MSCs in drug and gene delivery as well as MSC membrane coated nanoparticles for therapy and drug delivery, aiming to figure out the significant room for development and highlight the potential future directions.

Keywords: Cell membrane-coating; Cell-based target drug delivery system; Mesenchymal stem cells; Nanoparticles.

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Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic

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Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic

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